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3140 search results for:

Carbonic Anhydrase Inhibitor 

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  1. 18-07-2023 | OriginalPaper

    Pharmacological Properties of Sulfonamide Derivatives, New Inhibitors of Carbonic Anhydrase

    Selective blocking of individual isoforms of carbonic anhydrase (CA) is now one of the main directions in the development of its inhibitors. The new 1,2,4-oxadiazole-containing sulfonamides B12 and B13 predominantly block CA II and CA IX. The …

  2. 12-04-2021 | Acetazolamide | OriginalPaper

    An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial Protection

    Myocardial ischemia injury is a pressing issue which denotes the presence of heart diseases, such as coronary artery disease (CAD) and myocardial infarction (MI) [ 1 ]. Unfortunately, cellular hypoxic microenvironment significantly limits the …

  3. 01-03-2020 | Cataract | OriginalPaper

    Short-term outcomes of subtenon triamcinolone acetonide injections in patients with retinitis pigmentosa-associated cystoid macular edema unresponsive to carbonic anhydrase inhibitors

    Retinitis pigmentosa (RP) is a group of retinal diseases with linked to different inheritance patterns. It is composed of autosomal recessive, autosomal dominant and X-linked recessive forms in connection with the hereditary pattern [ 1 ].

  4. Open Access 01-12-2019 | Metabolic Alkalosis | Letter

    Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis

    We thank Meng-Si Luo et al. for their interest in our work, and for highlighting one the limitations of the literature in this field, namely the limited number of published randomized controlled trials (RCTS). In our conclusion, we do acknowledge …

  5. Open Access 01-12-2019 | Topiramate | OriginalPaper

    Disruption of the hippocampal and hypothalamic blood–brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate

    Type II diabetes mellitus, as well as obesity and consumption of Western diets, are known vascular risk factors for cognitive impairment and increased risk of dementia [ 1 , 2 ]. Emerging clinical evidence and studies in animal models of metabolic …

  6. Open Access 01-12-2018 | OriginalPaper

    Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials

    Metabolic alkalosis is common in patients with respiratory failure [ 1 , 2 ]. There is evidence that increased pH level in the cerebrospinal fluid may depress respiratory drive and may delay weaning in patients with respiratory failure on …

  7. 01-02-2018 | OriginalPaper

    The effects of topical carbonic anhydrase inhibitor in treatment of nystagmus

    Nystagmus refers to involuntary, typically conjugate, and often rhythmic oscillations of the eyes. The most common cause of nystagmus in children is infantile nystagmus syndrome (INS) [ 1 ]. The time of retinal image across the fovea was defined as …

  8. 01-08-2016 | OriginalPaper

    Effects of Brinzolamide, a Topical Carbonic Anhydrase Inhibitor, on Corneal Endothelial Cells

    The glaucoma treatment that has shown the best practical success is ophthalmic solutions to reduce intraocular pressure (IOP) [ 1 ]. Thus, many patients with glaucoma require the administration of anti-glaucoma drugs for a long period of time until …

  9. 01-10-2004 | OriginalPaper

    The Cyclooxygenase-2 Inhibitor Celecoxib Is a Potent Inhibitor of Human Carbonic Anhydrase II

    Cyclooxygenase-2 (COX-2) is up-regulated in stromal and inflammatory cells. The inducible COX-2 isoform is expressed during inflammation, in some cancers, and in brain tissue after global and focal ischemia. Tissue acidosis is a dominant factor in …

  10. 01-01-1999 | OriginalPaper

    The role of carbonic anhydrase inhibitors in the management of macular edema

    Medical treatment of cystoid macular edema (CME) with carbonic anhydrase inhibitors has been known for over a decade. Initial observations were based on experimental data which suggested that acetazolamide can increase fluid absorption across the …

  11. 01-05-2011 | OriginalPaper

    Generation and characterization of the first inhibitory antibody targeting tumour-associated carbonic anhydrase XII

    The carbonic anhydrases (CAs) constitute a family of almost ubiquitous enzymes of significant importance for many physiological and pathological processes. CAs reversely catalyse the conversion of CO2 + H2O to HCO3 − and H+, thereby contributing …

  12. 01-12-1998 | OriginalPaper

    Effects of the carbonic anhydrase inhibitor acetazolamide on splanchnic blood flow in anaesthetized rats

    The aim of the present study was to evaluate whether inhibition of the enzyme carbonic anhydrase with acetazolamide interfered with pancreatic islet and whole splanchnic blood perfusion in rats. Carbonic anhydrase is present both in the endocrine …

  13. 01-11-2015 | OriginalPaper

    The impact of immunohistochemical staining with ezrin-carbonic anhydrase IX and neuropilin-2 on prognosis in patients with metastatic renal cell cancer receiving tyrosine kinase inhibitors

    The identification of prognostic factors in patients with renal cell carcinoma (RCC) represents an area of increasing interest. In this retrospective study, we evaluated the prognostic role of carbonic anhydrase-IX, ezrin, and neuropilin in …

  14. Open Access 01-12-2013 | OriginalPaper

    Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines

    Bronchial carcinoid tumors are a group of neuroendocrine tumors (NETs), which constitute roughly 1–2% of all lung malignancies in the adult population and account for 31% of all cases of carcinoids [ 1 ]. These tumors are classified as typical (TC) …

  15. Open Access 01-08-2011 | OriginalPaper

    Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer

    In breast cancer patients, hematogenous tumor cell dissemination is a crucial step in tumor progression and blood-borne metastases account for the vast majority of breast cancer-related death. Circulating tumor cells (CTC) derived from primary …

  16. Open Access 01-12-2024 | Breast Cancer | ReviewPaper

    Advances in tumor microenvironment and underlying molecular mechanisms of bladder cancer: a systematic review

    Bladder cancer is one of the most frequent malignant tumors of the urinary system. The prevalence of bladder cancer among men and women is roughly 5:2, and both its incidence and death have been rising steadily over the past few years. At the …

  17. 01-10-2022 | Acetazolamide | OriginalPaper

    The Protective Effects of Acetazolamide Against Homocysteine-Induced Blood–Brain-Barrier Disruption by Regulating the Activation of the Wnt/β-Catenin Signaling Pathway

    Acetazolamide (AZA) is a carbonic anhydrase inhibitor (CAI) with neuroprotective effects. Hyperhomocysteinemia is associated with blood–brain-barrier (BBB) disruption in brain disorders. A previous study indicated that AZA might have a new role in …

  18. 01-03-2024 | Carbonic Anhydrase Inhibitor | News

    Diuretics/Steroids/Nepafenac

    Lack of efficacy
  19. 01-03-2024 | Trastuzumab | News

    Filgrastim/Trastuzumab-deruxtecan

    Capillary leak syndrome
  20. 01-05-2024 | Cytostatic Therapy | ReviewPaper

    Increased V-ATPase activity can lead to chemo-resistance in oral squamous cell carcinoma via autophagy induction: new insights

    Oral squamous cell carcinoma (OSCC) is a cancer type with a high rate of recurrence and a poor prognosis. Tumor chemo-resistance remains an issue for OSCC patients despite the availability of multimodal therapy options, which causes an increase in …

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