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3048 search results for:

Bullous Skin Disease 

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  1. 01-12-2020 | Common Pemphigus

    Estimated cut-off values for pemphigus severity classification according to pemphigus disease area index (PDAI), autoimmune bullous skin disorder intensity score (ABSIS), and anti-desmoglein 1 autoantibodies

    Pemphigus is a rare, but severe autoimmune-blistering disease, which involves skin and/or mucous membranes. In addition to the non-classical forms of pemphigus, there are two major types, including pemphigus vulgaris (PV) and pemphigus foliaceus …

  2. 01-03-2007 | Abstract

    Adjuvant therapy with rituximab appears to be effective but risky in refractory autoimmune bullous skin diseases

  3. 01-02-2018 | ReviewPaper

    Autoimmune Subepidermal Bullous Diseases of the Skin and Mucosae: Clinical Features, Diagnosis, and Management

    Autoimmune subepidermal blistering diseases of the skin and mucosae constitute a large group of sometimes devastating diseases, encompassing bullous pemphigoid, gestational pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita …

  4. Open Access 01-12-2015 | OriginalPaper

    Vitamin D and skeletal health in autoimmune bullous skin diseases: a case control study

    Recently, vitamin D has been suggested to influence the immune system, triggering or exacerbating autoimmunity [ 1 ], and hypovitaminosis D has been shown to be associated with the prevalence and severity of different autoimmune disorders [ 2 - 4 …

  5. 01-06-1999 | OriginalPaper

    Increased serum interleukin-15 levels in bullous skin diseases: correlation with disease intensity

  6. 01-08-2003 | OriginalPaper

    Autoimmune subepidermal bullous skin diseases: the impact of recent findings for the dermatopathologist

    In recent years improved knowledge of the mechanisms of intercellular and cell-matrix adhesion has led to better understanding of the blistering process in many bullous dermatoses. The wide characterisation of adhesion molecules has partially …

  7. Open Access 01-04-2007 | ReviewPaper

    The relevance of the IgG subclass of autoantibodies for blister induction in autoimmune bullous skin diseases

    Autoimmune bullous skin diseases are characterized by autoantibodies and T cells specific to structural proteins maintaining cell–cell and cell–matrix adhesion in the skin. Existing clinical and experimental evidence generally supports a …

  8. 01-05-1997 | OriginalPaper

    An Extract from Cultured Human Keratinocytes that Contains the Major Autoantigens Related to Autoimmune Bullous Skin Diseases

    Autoantibodies characteristic of autoimmune bullous skin diseases (AIBDs) can be detected by immunoblotting on epidermal, dermal, or bovine muzzle extracts. However, none of those substrates contain all the autoantigens involved in AIBDs, and the …

  9. Open Access 01-12-2012 | OriginalPaper

    Serological diagnosis of autoimmune bullous skin diseases: Prospective comparison of the BIOCHIP mosaic-based indirect immunofluorescence technique with the conventional multi-step single test strategy

    Autoimmune bullous disorders are characterized by autoantibodies against desmosomal proteins (in pemphigus), adhesion molecules of the dermal-epidermal junction (in pemphigoid diseases), and epidermal/ tissue transglutaminase (in dermatitis …

  10. Open Access 29-12-2023 | Bullous Pemphigoid | ReviewPaper

    Advancements in Bullous Pemphigoid Treatment: A Comprehensive Pipeline Update

    Bullous pemphigoid (BP) is a common autoimmune bullous disease affecting mainly the elderly, with rising incidence due to increased life expectancy. This disease is characterized by tense bullous lesions on normal or erythematous skin, accompanied …

  11. 01-07-2024 | Vaccination | OriginalPaper

    Understanding patient perspectives on vaccine decision making in adults with autoimmune bullous diseases: a qualitative study

    Patients with autoimmune bullous diseases are at an increased risk of infection, both from the underlying skin disease and from immunosuppressive treatments. Limited information is available on vaccine beliefs and behaviors in dermatology patients …

  12. Open Access 05-03-2024 | Bullous Pemphigoid | Online First

    Study Design of a Phase 2/3 Randomized Controlled Trial of Dupilumab in Adults with Bullous Pemphigoid: LIBERTY-BP ADEPT

    Bullous pemphigoid (BP) is the most common autoimmune skin-blistering disease. BP is associated with autoantibodies directed against the hemidesmosome transmembrane BP180 and/or intracellular BP230 proteins, which are responsible for adhesion and …

  13. Open Access 01-12-2021 | Bullous Pemphigoid | OriginalPaper

    The association of bullous pemphigoid with dipeptidyl-peptidase 4 inhibitors: a ten-year prospective observational study

    Bullous pemphigoid (BP) is the most common chronic bullous autoimmune skin disease which is characterized by the presentation of subepidermical blisters. It is considered as a disease of the elderly people and is associated with significant …

  14. Open Access 01-12-2021 | Bullous Pemphigoid | OriginalPaper

    Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England

    Bullous pemphigoid is a rare blistering skin disease that predominantly affects older people [ 1 ]. Following a diagnosis of bullous pemphigoid, individuals affected are almost three times more likely to die than their peers [ 1 ]. Current …

  15. Open Access 01-12-2021 | Bullous Pemphigoid | ReviewPaper

    Bullous pemphigoid in diabetic patients treated by gliptins: the other side of the coin

    Bullous pemphigoid (BP) is the most common autoimmune bullous skin disease that affects primarily patients older than 60 years. The majority of BP cases are spontaneous, but BP can also be triggered by certain drugs’ exposures. Since 2011, a …

  16. Open Access 29-03-2024 | Erythema Exsudativum Multiforme | Online First

    PD-L1 expression in keratinocyte and infiltration of CD4 + T lymphocyte can predict a severe type of erythema multiforme major induced by the anti-PD-1 antibody, pembrolizumab

    Skin toxicity is the most common adverse event of treatment with immune check point inhibitors. Among them, erythema multiforme is a rare occurrence with a frequency of 4%, with most of the cases developing grade 1/2 disease. We experienced high …

  17. Open Access 01-12-2023 | Digital Volume Tomography | OriginalPaper

    A rare case of pemphigus vulgaris disguised as a malignant gingival ulcer

    Pemphigus vulgaris (PV) is a severe and chronic autoimmune bullous disease of the skin and mucosa [ 1 ]. The mucosal lesions were blisters and erosion. PV usually begins as multiple painful non-healing erosions of the oral mucosa that are followed …

  18. Open Access 01-12-2024 | Lichen Planus | OriginalPaper

    The relationship between clinical symptoms of oral lichen planus and quality of life related to oral health

    Lichen planus (LP) is a chronic and relatively common mucocutaneous disease that often affects the oral mucosa. The exact cause of the disease is yet to be discovered; however existing evidence suggests the involvement of immunologic processes in …

  19. 01-07-2024 | Atopic Dermatitis | ReviewPaper

    The role of thymic stromal lymphopoietin in cutaneous disorders

    Thymic Stromal Lymphopoietin (TSLP) is an important cytokine that invokes early immune responses. TSLP, an IL-7-like cytokine encoded by the TSLP gene, activates JAK1 and JAK2 signaling pathways, stimulating dendritic cells to induce inflammatory …

  20. 14-05-2024 | Pyoderma Gangrenosum | Online First

    Approach to the Atypical Wound

    The heterogeneity of atypical wounds can present diagnostic and therapeutic challenges; however, as the prevalence of atypical wounds grows worldwide, prompt and accurate management is increasingly an essential skill for dermatologists. Addressing …

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