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4932 search results for:

Oligodendroglioma 

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  1. 31-01-2024 | Oligodendroglioma | OriginalPaper

    Rise of oligodendroglioma hypermutator phenotype from a subclone harboring TP53 mutation after TMZ treatment

    Oligodendrogliomas characterized and defined by 1p/19q co-deletion are slowly growing tumors showing better prognosis than astrocytomas. TP53 mutation is rare in oligodendrogliomas while the vast majority of astrocytomas harbor the mutation …

  2. 02-04-2024 | Oligodendroglioma | ReviewPaper

    Oligodendroglioma, IDH-mutant and 1p/19q-codeleted-prognostic factors, standard of care and chemotherapy, and future perspectives with neoadjuvant strategy

    Oligodendroglioma, IDH-mutant and 1p/19q-codeleted is known for their relative chemosensitivity and indolent clinical course among diffuse gliomas of adult type. Based on the data from phase 3 clinical trials, the standard of post-surgical care …

  3. 26-03-2024 | Oligodendroglioma | Online First

    Perfusion percentage signal recovery and a mundane chicken wire: what could they have to do in oligodendrogliomas?

  4. Open Access 29-01-2024 | Oligodendroglioma | Online First

    Differentiating IDH-mutant astrocytomas and 1p19q-codeleted oligodendrogliomas using DSC-PWI: high performance through cerebral blood volume and percentage of signal recovery percentiles

    The imaging-based presurgical differentiation between astrocytomas and oligodendrogliomas represents an unsolved challenge in neuro-oncology. This differentiation has potential implications for diagnosis and initial patient management in several …

  5. 18-12-2023 | Online First

    Intratumoral calcification seems like the tree rings for tumours such as oligodendroglioma

  6. 21-12-2023 | Oligodendroglioma | OriginalPaper

    The cortical high-flow sign of oligodendroglioma, IDH-mutant and 1p/19q-codeleted: comparison between arterial spin labeling and dynamic susceptibility contrast methods

    The cortical high-flow sign with the non-enhancing area on arterial spin labeling perfusion-weighted imaging (ASL-PWI) was reportedly found to be more frequent in diffuse gliomas with oligodendroglioma, IDH-mutant and 1p/19q codeleted (ODG …

  7. 16-11-2023 | Oligodendroglioma | Online First

    Intratumoral calcification: not only a diagnostic but also a prognostic indicator in oligodendrogliomas

    Oligodendroglioma (ODG) is the third most common glioma, accounting for 5–20% of all intracranial glial tumors, outranked only by glioblastoma and astrocytoma [ 1 , 2 ]. They generally show a more indolent clinical course, increased therapeutic …

  8. Open Access 15-01-2024 | Astrocytoma | OriginalPaper

    Comparison of diagnostic performance of radiologist- and AI-based assessments of T2-FLAIR mismatch sign and quantitative assessment using synthetic MRI in the differential diagnosis between astrocytoma, IDH-mutant and oligodendroglioma, IDH-mutant and 1p/19q-codeleted

    Isocitrate dehydrogenase (IDH) enzymes play a key role in glioma tumorigenesis [ 1 ]. A previous study revealed that IDH mutations were more frequently observed in diffuse low-grade gliomas, including astrocytomas and oligodendrogliomas [ 2 ]. The …

  9. Open Access 25-12-2022 | Astrocytoma | ReviewPaper

    Conventional and emerging treatments of astrocytomas and oligodendrogliomas

    Relevant advances in the molecular diagnostics of brain tumors have been made in recent years, which led to the inclusion of genetic markers into the current 5th edition of the WHO classification of tumors of the central nervous system [ 1 ].

  10. Open Access 21-08-2023 | Oligodendroglioma | OriginalPaper

    Long-term follow up of patients with WHO grade 2 oligodendroglioma

    Oligodendrogliomas are usually slow-growing primary CNS tumors that often give rise to first-time seizures in young to middle-aged adults. The tumors are classified as diffuse lower grade gliomas (LGG) together with isocitrate dehydrogenase ( IDH) …

  11. 15-12-2022 | Astrocytoma | OriginalPaper

    The sinuous, wave-like intratumoral-wall sign is a sensitive and specific radiological biomarker for oligodendrogliomas

    Adult diffuse lower-grade gliomas (LGGs, World Health Organization (WHO) grades 2–3), most frequently affect young and middle-aged patients and compromise quality and life expectancy [ 1 ]. The 2016 and 2021 WHO classification systems of brain …

  12. Open Access 01-12-2022 | Glioma | OriginalPaper

    Integrated proteomic analysis of low-grade gliomas reveals contributions of 1p-19q co-deletion to oligodendroglioma

    Diffusely infiltrative low-grade gliomas (LGG) are primary brain tumours that arise predominantly in the cerebral hemispheres of younger adults. LGG can display either astrocytic or oligodendroglial histology and do not express malignant …

  13. 01-12-2023 | Magnetic Resonance Imaging | OriginalPaper

    Apparent diffusion coefficient values effectively predict cell proliferation and determine oligodendroglioma grade

    This study aims to evaluate the value of conventional magnetic resonance imaging (MRI) features and apparent diffusion coefficient (ADC) values in differentiating oligodendroglioma of various grades and explore the correlation between ADC and …

  14. Open Access 01-12-2021 | Oligodendroglioma | OriginalPaper

    Synchronous supratentorial and infratentorial oligodendrogliomas with incongruous IDH1 mutations, a case report

    Infratentorial oligodendrogliomas, a rare pathological entity, are generally considered metastatic lesions from supratentorial primary tumors. Here, we report the case of a 23-year-old man presenting with a histopathologically confirmed right …

  15. Open Access 02-05-2023 | Astrocytoma | OriginalPaper

    Oligodendrogliomas tend to infiltrate the frontal aslant tract, whereas astrocytomas tend to displace it

    MR-tractography is increasingly used as a clinical tool to visualize subcortical tracts and to plan brain tumor surgery [ 1 ]. The anatomical relationship between a brain tumor and nearby subcortical tracts can be used to determine a safe surgical …

  16. 01-07-2021 | Glioma

    A single institution retrospective analysis on survival based on treatment paradigms for patients with anaplastic oligodendroglioma

    Anaplastic oligodendrogliomas (AO) are grade III tumors which harbor the 1p/19q co-deletion, and are known to be chemosensitive [ 1 , 2 ]. Current standard of care treatment is surgical resection followed by radiation therapy (RT) and chemotherapy …

  17. 11-04-2023 | Glioma | OriginalPaper

    Spatial metabolic heterogeneity of oligodendrogliomas at single-cell resolution

    Oligodendrogliomas are a type of rare and incurable gliomas whose metabolic profiles have yet to be fully examined. The present study examined the spatial differences in metabolic landscapes underlying oligodendrogliomas and should provide unique …

  18. 01-06-2021 | Glioma

    PCV chemotherapy alone for WHO grade 2 oligodendroglioma: prolonged disease control with low risk of malignant progression

    Oligodendrogliomas occur predominantly in young to middle adulthood and often show a prolonged, indolent clinical course. The World Health Organization (WHO) histologically distinguishes diffuse, WHO grade 2 from anaplastic, WHO grade 3 …

  19. Open Access 01-12-2020 | Oligodendroglioma | OriginalPaper

    Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

    Oligodendroglioma is the third most common type of diffusely infiltrative glioma, with an annual incidence of about 0.6 cases per 100,000 people [ 1 ] and accounts for 4–15% of all gliomas [ 2 ]. In the revised version of the WHO classification of …

  20. Open Access 01-12-2021 | Oligodendroglioma | OriginalPaper

    Loss of H3K27 trimethylation is frequent in IDH1-R132H but not in non-canonical IDH1/2 mutated and 1p/19q codeleted oligodendroglioma: a Japanese cohort study

    Oligodendrogliomas are defined by mutation in isocitrate dehydrogenase (NADP(+)) (IDH)1/2 genes and chromosome 1p/19q codeletion. World Health Organisation diagnosis endorses testing for 1p/19q codeletion to distinguish IDH mutant (Mut) …

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