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401 

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  1. Open Access 01-12-2024 | OriginalPaper

    The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells

    Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. Significantly, some MTA-treated cancer cells escape death in mitosis, exit mitosis and become malignant polyploid giant …

  2. 15-12-2023 | OriginalPaper

    A 5G-based telerobotic ultrasound system provides qualified abdominal ultrasound services for patients on a rural island: a prospective and comparative study of 401 patients

    Ultrasound (US) imaging plays a vital role in diagnosing abdominal diseases due to its convenience and noninvasive advantages [ 1 ]. As reported by the World Health Organization, diagnostic imaging is required in 20–30% of clinical cases. Among …

  3. Open Access 01-12-2023 | Tyrosine Kinase Inhibitors | OriginalPaper

    Anti-cancer effect of afatinib, dual inhibitor of HER2 and EGFR, on novel mutation HER2 E401G in models of patient-derived cancer

    Multi-gene panel testing of cancer by using next-generation sequencing (NGS) is now widespread, leading to proposals for optimal treatment of individual cancer patients in the clinical practice of oncology [ 1 , 2 ]. Therapeutic approaches …

  4. 01-12-2022 | Solid Tumor

    A first-in-human phase 1/2 study of FGF401 and combination of FGF401 with spartalizumab in patients with hepatocellular carcinoma or biomarker-selected solid tumors

    Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the fourth most common cause of cancer-related deaths [ 1 , 2 ]. Most patients present with unresectable progressive disease with approximate survival of one year [ 3 ].

  5. 01-10-2019 | Allopurinol | OriginalPaper

    In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401

    c-Met is a receptor tyrosine kinase for hepatocyte growth factor. c-Met abnormal activation and mutations are believed to be a driving factor for tumorigenesis, metastasis, poor prognosis, and drug resistance [ 1 – 4 ]. c-Met has become a …

  6. Open Access 31-01-2022 | Splenectomy | OriginalPaper

    401 consecutive minimally invasive distal pancreatectomies: lessons learned from 20 years of experience

    The study was performed according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) and Strengthening the Reporting of Cohort Studies in Surgery (STROCSS) guidelines [ 20 , 21 ] . Patients undergoing MIDP between …

  7. Open Access 01-10-2019 | Lymphoma | OriginalPaper

    Absorption, Distribution, and Binding Profile of ME-401, a Potent and Selective Oral Small-Molecule Inhibitor of Phosphatidylinositol 3-Kinase δ (PI3Kδ) in Animal and B-Cell Lymphoma Models

    Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase with a catalytic subunit that exists in four different isoforms (α, β, γ, and δ). The δ isoform is highly restricted to hematopoietic cells and plays a key role in normal B-cell development …

  8. 13-01-2022 | Positron Emission Tomography | OriginalPaper

    First-in-human in vivo imaging and quantification of monoacylglycerol lipase in the brain: a PET study with 18F-T-401

    The endocannabinoid system is responsible for intercellular signaling involved in a wide variety of physiological processes, including regulation of cardiovascular, gastrointestinal, and brain functions. In the central nervous system (CNS) …

  9. Open Access 01-12-2021 | Cholecystitis | OriginalPaper

    Evaluation of the conversion rate as it relates to preoperative risk factors and surgeon experience: a retrospective study of 4013 patients undergoing elective laparoscopic cholecystectomy

    In all, 10–15% of developed societies are affected by cholecystolithiasis [ 1 ]. The number of cholecystectomies that are performed has gradually increased worldwide since 1950. With the introduction of the operative technique for laparoscopic …

  10. Open Access 15-09-2022 | Lymphoma | OriginalPaper

    Zandelisib (ME-401) in Japanese patients with relapsed or refractory indolent non-Hodgkin’s lymphoma: an open-label, multicenter, dose-escalation phase 1 study

    The selective phosphatidylinositol 3-kinase δ inhibitor zandelisib demonstrated favorable safety and efficacy [objective response rate (ORR) 79%] in patients with B-cell malignancies in a phase 1b study in the US and Switzerland. In this phase 1 …

  11. 01-05-2021 | Pharmacokinetics | OriginalPaper

    First-in-Human Studies to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Novel 5-HT4 Partial Agonist, SUVN-D4010, in Healthy Adult and Elderly Subjects

    Cognitive impairment involves a group of symptoms that include difficulty with remembering, learning, and making decisions, which affect a person’s ability to perform daily activities. Cognitive impairment can be mild or severe. Mild cognitive …

  12. 11-04-2022 | Erratum

    Correction to: First‑in‑human in vivo imaging and quantification of monoacylglycerol lipase in the brain: a PET study with 18F‑T‑401

  13. 01-02-2022 | Gastrectomy

    Effectiveness and safety of robotic gastrectomy versus laparoscopic gastrectomy for gastric cancer: a meta-analysis of 12,401 gastric cancer patients

    Advanced minimally invasive techniques, such as robotic surgeries, are applied increasingly frequently around the world and are primarily used to improve the surgical outcomes of laparoscopic gastrectomy (LG). Against that background, we conducted …

  14. 01-06-2018 | News

    Sl-401

    Various toxicities: 2 case reports
  15. Open Access 01-08-2019 | Pharmacokinetics | BriefCommunication

    Clinical Pharmacokinetics of a Lipid-Based Formulation of Risperidone, VAL401: Analysis of a Single Dose in an Open-Label Trial of Late-Stage Cancer Patients

    Risperidone has a long history of use as an atypical antipsychotic; it appeared on the WHO list of essential medicines in 2013 [ 1 ] and is the subject of positive Cochrane reviews supporting its use in schizophrenia [ 2 ]. Risperidone use is …

  16. Open Access 01-03-2021 | Solid Tumor | OriginalPaper

    Phase I, first-in-human trial of programmed cell death receptor-1 (PD-1) inhibitor, JTX-4014, in adult patients with advanced, refractory, solid tumors

    The approvals of PD-1 inhibitors (PD-1is), including pembrolizumab and nivolumab, have caused a paradigm shift in immuno-oncology therapeutics, providing durable remissions for many patients with cancer [ 1 – 4 ]. Patients who achieve objective …

  17. 01-10-2003 | Abstract

    NCX 4016: less mucosal injury than aspirin

  18. Open Access 01-12-2018 | OriginalPaper

    First pediatric experience of SL-401, a CD123-targeted therapy, in patients with blastic plasmacytoid dendritic cell neoplasm: report of three cases

    Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a highly aggressive hematological malignancy that primarily involves bone marrow (BM) and/or skin; secondary sites include lymph nodes, soft tissue, and central nervous system [ 1 , 2 ]. BPDCN …

  19. 01-11-2015 | OriginalPaper

    Association between CLPTM1L–TERT rs401681 polymorphism and risk of pancreatic cancer: a meta-analysis

    Telomere biology plays a critical and complex role in the initiation and progression of cancer. Several recent studies have provided evidence that rs401681 polymorphisms in intronic region of cleft lip and palate trans-membrane 1-like (CLPTM1L) …

  20. Open Access 01-10-2008 | Abstract

    401 New dynamic gradient echo cine for detection of intracardiac shunts

    CMR is a useful diagnostic tool in the evaluation of patients with intracardiac shunting. Balanced gradient echo sequences provide excellent temporal and spatial resolution. Fast gradient echo techniques are more sensitive to flow artifacts and …

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