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Virology Journal
Published in: Virology Journal 1/2023

Open Access 01-12-2023 | Thrombocytopenia | Review

Genetic variants of Dabie bandavirus: classification and biological/clinical implications

Authors: Bingyan Liu, Jie Zhu, Tengfei He, Zhenhua Zhang

Published in: Virology Journal | Issue 1/2023

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Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by Dabie bandavirus (DBV), a novel Bandavirus in the family Phenuiviridae. The first case of SFTS was reported in China, followed by cases in Japan, South Korea, Taiwan and Vietnam. With clinical manifestations including fever, leukopenia, thrombocytopenia, and gastrointestinal symptoms, SFTS has a fatality rate of approximately 10%. In recent years, an increasing number of viral strains have been isolated and sequenced, and several research groups have attempted to classify the different genotypes of DBV. Additionally, accumulating evidence indicates certain correlations between the genetic makeup and biological/clinical manifestations of the virus. Here, we attempted to evaluate the genetic classification of different groups, align the genotypic nomenclature in different studies, summarize the distribution of different genotypes, and review the biological and clinical implications of DBV genetic variations.
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Metadata
Title
Genetic variants of Dabie bandavirus: classification and biological/clinical implications
Authors
Bingyan Liu
Jie Zhu
Tengfei He
Zhenhua Zhang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2023
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-023-02033-y

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