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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2011

01-04-2011 | Review

The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies

Authors: Nadia Sassi, Lilia Laadhar, Maha Driss, Meriam Kallel-Sellami, Slaheddine Sellami, Sondes Makni

Published in: Arthritis Research & Therapy | Issue 2/2011

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Abstract

Osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing of the population, it is becoming a major public health problem. The involvement of certain signaling pathways, such as the Notch pathway, during cartilage pathology has been reported. In this review, we report on studies that investigated the expression pattern of the Notch family members in articular cartilage and the eventual involvement of this pathway in the modulation of the physiology and pathology of chondrocytes. Temporal and/or spatial modulation of this signaling pathway may help these cells to synthesize a new functional extracellular matrix and restore the functional properties of the articular cartilage.
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Metadata
Title
The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies
Authors
Nadia Sassi
Lilia Laadhar
Maha Driss
Meriam Kallel-Sellami
Slaheddine Sellami
Sondes Makni
Publication date
01-04-2011
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2011
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3255

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