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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2011

01-04-2011 | Review

Abnormalities of T cell signaling in systemic lupus erythematosus

Authors: Vaishali R Moulton, George C Tsokos

Published in: Arthritis Research & Therapy | Issue 2/2011

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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate B cell responses and also infiltrate target tissues, leading to tissue damage. Abnormal signaling events link to defective gene transcription and altered cytokine production, contributing to the aberrant phenotype of T cells in SLE. Study of signaling and gene transcription abnormalities in SLE T cells has led to the identification of novel targets for therapy.
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Metadata
Title
Abnormalities of T cell signaling in systemic lupus erythematosus
Authors
Vaishali R Moulton
George C Tsokos
Publication date
01-04-2011
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2011
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3251

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