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01-06-2018 | Review Article

The possible factors affecting microglial activation in cases of obesity with cognitive dysfunction

Authors: Titikorn Chunchai, Nipon Chattipakorn, Siriporn C. Chattipakorn

Published in: Metabolic Brain Disease | Issue 3/2018

Abstract

Obesity has reached epidemic proportions in many countries around the world. Several studies have reported that obesity can lead to the development of cognitive decline. There is increasing evidence to demonstrate that microglia play a crucial role in cognitive decline in cases of obesity, Alzheimer’s disease and also in the aging process. Although there have been several studies into microglia over the past decades, the mechanistic link between microglia and cognitive decline in obese models is still not fully understood. In this review, the current available evidence from both in vitro and in vivo investigations regarding the association between the alteration in microglial activity in different obese models with respect to cognition are included. The metabolite profiles from obesity, adiposity, dietary and hormone affected microglial activation and its function in the brain are comprehensively summarized. In addition, the possible roles of microglial activation in relation to cognitive dysfunction are also presented and discussed. To ensure a balanced perspective controversial reports regarding these issues are included and discussed.

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Title: The possible factors affecting microglial activation in cases of obesity with cognitive dysfunction
Authors: Titikorn Chunchai
Nipon Chattipakorn
Siriporn C. Chattipakorn
Publication date: 01-06-2018
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 3/2018
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-0151-9

At a glance: The STEP trials

Springer Medicine

The possible factors affecting microglial activation in cases of obesity with cognitive dysfunction

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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