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01-06-2018 | Original Article

Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus

Authors: Nasra Naeim Ayuob, Manal Galal Abd El Wahab, Soad Shaker Ali, Hanem Saad Abdel-Tawab

Published in: Metabolic Brain Disease | Issue 3/2018

Abstract

Alzheimer’s disease (AD), one of the progressive neurodegenerative diseases might be associated with exposure to stress and altered living conditions. This study aimed to evaluate the effectiveness of Ocimum basilicum (OB) essential oils in improving the neurodegenerative-like changes induced in mice after exposed to chronic unpredictable mild stress (CUMS). Forty male Swiss albino mice divided into four groups (n = 10); the control, CUMS, CUMS + Fluoxetine, CUMS + OB were used. Behavioral tests, serum corticosterone level, hippocampus protein level of the glucocorticoid receptors (GRs) and brain-dreived neurotropic factor (BDNF) were determined after exposure to CUMS. Hippocampus was histopathologically examined. Data were analyzed using statistical package for the social sciences (SPSS) and P value of less than 0.05 was considered significant. OB diminished the depression manifestation as well as impaired short term memory observed in the mice after exposure to the CUMS as evidenced by the forced swimming and elevated plus maze test. OB also up-regulated the serum corticosterone level, hippocampal protein level of the glucocorticoid receptor and the brain-derived neurotropic factor and reduced the neurodegenerative and atrophic changes induced in the hippocampus after exposure to CUMS. Essential oils of OB alleviated the memory impairment and hippocampal neurodegenerative changes induced by exposure to the chronic unpredictable stress indicating that it is the time to test its effectiveness on patients suffering from Alzheimer disease.

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Title: Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus
Authors: Nasra Naeim Ayuob
Manal Galal Abd El Wahab
Soad Shaker Ali
Hanem Saad Abdel-Tawab
Publication date: 01-06-2018
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 3/2018
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-0173-3

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Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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