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01-06-2018 | Original Article

A gender dimorphism in up-regulation of BACE1 gene expression in schizophrenia

Authors: Nafiseh Nafisi-Far, Soudeh Ghafouri-Fard, Akram Sadat Tabatabaei Panah, Arezou Sayad, Mohammad Taheri

Published in: Metabolic Brain Disease | Issue 3/2018

Abstract

Schizophrenia has long been considered as a devastating brain disorder in which both genetic and environmental factors are involved. The BACE1 gene is one of the most important susceptibility genes for this disorder. However, the changes in BACE1 expression in schizophrenic patients compared with healthy subjects have not been evaluated yet. In this case-control study, we examined BACE1 expression in a group of 50 patients with schizophrenia and 50 healthy controls. The level of BACE1 gene expression was measured using Real-Time PCR. Substantial increase in gene expression was detected in the patients compared with normal individuals (P = 0.001). Furthermore, a gender dimorphism was observed in BACE1 gene expression in the patients in a way that the male patients manifested a statistically significant higher levels of BACE1 expression (P = 0.002). BACE1 might be implicated in the pathogenesis of schizophrenia. Besides, BACE1 physiology may be gender -based at some levels. Our findings warrant an investigation of BACE1 gene in a larger number of cases and controls.

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Title: A gender dimorphism in up-regulation of BACE1 gene expression in schizophrenia
Authors: Nafiseh Nafisi-Far
Soudeh Ghafouri-Fard
Akram Sadat Tabatabaei Panah
Arezou Sayad
Mohammad Taheri
Publication date: 01-06-2018
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 3/2018
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0205-7

At a glance: The STEP trials

Springer Medicine

A gender dimorphism in up-regulation of BACE1 gene expression in schizophrenia

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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