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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2021

Open Access 01-12-2021 | Review

The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus?

Authors: Henning Madry, Susanne Grässel, Ulrich Nöth, Borna Relja, Anke Bernstein, Denitsa Docheva, Max Daniel Kauther, Jan Christoph Katthagen, Rainer Bader, Martijn van Griensven, Dieter C. Wirtz, Michael J. Raschke, Markus Huber-Lang

Published in: European Journal of Medical Research | Issue 1/2021

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Abstract

Orthopaedic and trauma research is a gateway to better health and mobility, reflecting the ever-increasing and complex burden of musculoskeletal diseases and injuries in Germany, Europe and worldwide. Basic science in orthopaedics and traumatology addresses the complete organism down to the molecule among an entire life of musculoskeletal mobility. Reflecting the complex and intertwined underlying mechanisms, cooperative research in this field has discovered important mechanisms on the molecular, cellular and organ levels, which subsequently led to innovative diagnostic and therapeutic strategies that reduced individual suffering as well as the burden on the society. However, research efforts are considerably threatened by economical pressures on clinicians and scientists, growing obstacles for urgently needed translational animal research, and insufficient funding. Although sophisticated science is feasible and realized in ever more individual research groups, a main goal of the multidisciplinary members of the Basic Science Section of the German Society for Orthopaedics and Trauma Surgery is to generate overarching structures and networks to answer to the growing clinical needs. The future of basic science in orthopaedics and traumatology can only be managed by an even more intensified exchange between basic scientists and clinicians while fuelling enthusiasm of talented junior scientists and clinicians. Prioritized future projects will master a broad range of opportunities from artificial intelligence, gene- and nano-technologies to large-scale, multi-centre clinical studies. Like Prometheus in the ancient Greek myth, transferring the elucidating knowledge from basic science to the real (clinical) world will reduce the individual suffering from orthopaedic diseases and trauma as well as their socio-economic impact.
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Metadata
Title
The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus?
Authors
Henning Madry
Susanne Grässel
Ulrich Nöth
Borna Relja
Anke Bernstein
Denitsa Docheva
Max Daniel Kauther
Jan Christoph Katthagen
Rainer Bader
Martijn van Griensven
Dieter C. Wirtz
Michael J. Raschke
Markus Huber-Lang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2021
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-021-00521-x

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