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Clinical Reviews in Allergy & Immunology
Published in: Clinical Reviews in Allergy & Immunology 3/2012

01-06-2012

The Clinical Significance of 25OH-Vitamin D Status in Celiac Disease

Authors: Aaron Lerner, Yinon Shapira, Nancy Agmon-Levin, Avi Pacht, Dana Ben-Ami Shor, Hoyos Marcus López, Maria Sanchez-Castanon, Yehuda Shoenfeld

Published in: Clinical Reviews in Allergy & Immunology | Issue 3/2012

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Abstract

Reduced bone mineral density is frequently found especially in adult celiac disease (CD) and dietary guidelines favor vitamin D supplementation in adults and children with CD. Vitamin D serum levels were investigated in CD populations in order to challenge its routine supplementation. Israeli (61), Spanish (59), CD children (groups 1 and 5, respectively) were compared to children with nonspecific abdominal pain (56), their parents (84) and Spanish adult CD patients (22) (group 2, 3, 4, respectively). 25(OH)-vitamin D was checked by LIAISON chemiluminescent immunoassays. Groups 5 and 1 had the highest levels compared to groups 4 and 3 with the lowest levels. The levels in groups 1 and 2 were comparable. Concerning 25(OH)-vitamin D sera levels, only the difference between group 5 and 4 was statistically significant (30.3 ± 12.3 and 20.2 ± 10.5 ng/ml, respectively p = 0.003). When vitamin D was splitted above and below 20 ng/ml level, 54.5% of Spanish adult CD had vitamin D deficiency compared to 16.9% of the local CD children (p = 0.001). 29.6% of group 2 had deficient levels compared to their parents with 50% (p = 0.019). In conclusion, Vitamin D sera levels negatively correlate with age. Thus, mainly adult CD population should be assessed for vitamin D levels and supplemented accordingly.
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Metadata
Title
The Clinical Significance of 25OH-Vitamin D Status in Celiac Disease
Authors
Aaron Lerner
Yinon Shapira
Nancy Agmon-Levin
Avi Pacht
Dana Ben-Ami Shor
Hoyos Marcus López
Maria Sanchez-Castanon
Yehuda Shoenfeld
Publication date
01-06-2012
Publisher
Humana Press Inc
Published in
Clinical Reviews in Allergy & Immunology / Issue 3/2012
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-010-8237-8

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