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EJNMMI Research
Published in: EJNMMI Research 1/2021

Open Access 01-12-2021 | Targeted Therapy | Review

Rationale for MYC imaging and targeting in pancreatic cancer

Authors: Günter Schneider, Matthias Wirth, Ulrich Keller, Dieter Saur

Published in: EJNMMI Research | Issue 1/2021

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Abstract

The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The development and successful implementation of precision oncology in other gastrointestinal tumor entities point to opportunities also for PDAC. Therefore, markers linked to specific therapeutic responses and important subgroups of the disease are needed. The MYC oncogene is a relevant driver in PDAC and is linked to drug resistance and sensitivity. Here, we update recent insights into MYC biology in PDAC, summarize the connections between MYC and drug responses, and point to an opportunity to image MYC non-invasively. In sum, we propose MYC-associated biology as a basis for the development of concepts for precision oncology in PDAC.
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Metadata
Title
Rationale for MYC imaging and targeting in pancreatic cancer
Authors
Günter Schneider
Matthias Wirth
Ulrich Keller
Dieter Saur
Publication date
01-12-2021
Publisher
Springer Berlin Heidelberg
Published in
EJNMMI Research / Issue 1/2021
Electronic ISSN: 2191-219X
DOI
https://doi.org/10.1186/s13550-021-00843-1

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