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01-06-2021 | Targeted Therapy | Review Article

PARP inhibitors: shifting the paradigm in the treatment of pancreatic cancer

Authors: Devashish Desai, Pushti Khandwala, Meghana Parsi, Rashmika Potdar

Published in: Medical Oncology | Issue 6/2021

Abstract

Pancreatic cancer, being one of the most fatal cancers, is the 7th leading cause of death globally. Cancer that is resistant to current treatment proves that there is a need for personalized and targeted therapy, based on the tumor and genomic markers. Pembrolizumab and Larotrectinib are examples of current medications used as targeted therapy in pancreatic cancer. Pancreatic cancer has many different molecular subgroups, providing the opportunity for the development of new drugs that can target these groups. Poly (ADP-Ribose) polymerase inhibitors (PARPi) are a group of drugs inhibiting PARP to decrease the stability of the cancer cells. Currently, PARPi are mostly used in ovarian and breast cancer. There are multiple studies that have shown positive effects of PARPi in decreasing the tumor burden in advanced pancreatic cancer. PARPi are the future of pancreatic cancer management, and hence it is important to understand their mechanism, resistance pathways, and their application in the real world.

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Title: PARP inhibitors: shifting the paradigm in the treatment of pancreatic cancer
Authors: Devashish Desai
Pushti Khandwala
Meghana Parsi
Rashmika Potdar
Publication date: 01-06-2021
Publisher: Springer US
Keywords: Targeted Therapy
Pancreatic Cancer
Pancreatic Cancer
Published in: Medical Oncology / Issue 6/2021
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-021-01507-9

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