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BMC Neurology
Published in: BMC Neurology 1/2024

Open Access 01-12-2024 | Stroke | Research

Brain frailty associated with stroke events in anterior circulation large artery occlusion

Authors: Jing Tian, Kun Zhang, Junzhao Cui, Jin Qin, Binbin Wang, Lixia Zhou, Tong Li, Kailin Bu, Zhongzhong Li, Lin Liu, Qisong Wang, Si Yuan, Lina Ma, Ye Wang, Rui Wang, Chaoyue Meng, Biyi Zhou, Li Guo, Xiaoyun Liu

Published in: BMC Neurology | Issue 1/2024

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Abstract

Objective

To investigate the factors associated with brain frailty and the effect of brain frailty in patients with anterior circulation large artery occlusion (AC-LAO).

Methods

1100 patients with AC-LVO consecutively admitted to the Second Hospital of Hebei Medical University, North China between June 2016 and April 2018 were retrospectively analyzed. The variables associated with brain frailty and stroke outcome were analyzed by ANOVA analysis, the Mann-Whitney U test and multiple linear regression. Based on previous research. Brain frailty score comprises 1 point each for white matter hyperintensity (WMH), old infarction lesions, and cerebral atrophy among 983 participants with baseline brain magnetic resonance imaging or computed tomography.

Results

Among AC-LAO participants, baseline brain frailty score ≥ 1 was common (750/983, 76.3%). Duration of hypertension > 5 years (mean difference [MD] 0.236, 95% CI 0.077, 0.395, p = 0.004), multiple vessel occlusion (MD 0.339, 95% CI 0.068, 0.611, p = 0.014) and basal ganglia infarction (MD -0.308, 95% CI -0.456, -0.160, p < 0.001) were independently associated with brain frailty score. Brain frailty score was independently associated with stroke events, and higher brain frailty scores were associated with higher rates of stroke events (p < 0.001). However, brain frailty has no independent effect on short-term outcome of ACI in AC-LAO patients.

Conclusions

In AC-LAO patients, older age, duration of hypertension > 5 years, and multiple vessel occlusion influenced the brain frailty score. Brain frailty score was independently associated with the occurrence of stroke events in AC-LAO patients.
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Metadata
Title
Brain frailty associated with stroke events in anterior circulation large artery occlusion
Authors
Jing Tian
Kun Zhang
Junzhao Cui
Jin Qin
Binbin Wang
Lixia Zhou
Tong Li
Kailin Bu
Zhongzhong Li
Lin Liu
Qisong Wang
Si Yuan
Lina Ma
Ye Wang
Rui Wang
Chaoyue Meng
Biyi Zhou
Li Guo
Xiaoyun Liu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2024
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-024-03566-7

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