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Open Access 01-12-2014 | Review

Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke

Authors: Pawel J Winklewski, Marek Radkowski, Urszula Demkow

Published in: Journal of Neuroinflammation | Issue 1/2014

Abstract

The immune system response and inflammation play a key role in brain injury during and after a stroke. The acute immune response is responsible for secondary brain tissue damage immediately after the stroke, followed by immunosuppression due to sympathetic nervous system activation. The latter increases risk of infection complications, such as pneumonia. The pneumonia-related inflammatory state can release a bystander autoimmune response against central nervous system antigens, thereby initiating a vicious circle. The aim of this review is to summarize the relationship between ischemic stroke, sympathetic nervous system activation and pulmonary infection.

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Title: Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke
Authors: Pawel J Winklewski
Marek Radkowski
Urszula Demkow
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Journal of Neuroinflammation / Issue 1/2014
Electronic ISSN: 1742-2094
DOI: https://doi.org/10.1186/s12974-014-0213-4

At a glance: The STEP trials

Springer Medicine

Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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