Skip to main content

Hyperoxemia in acute brain injury: too much of a good thing?

Accumulating data suggest excessive oxygen use in brain-injured ICU patients contributes to secondary brain injury. The optimal oxygenation approach remains uncertain, but clinicians must balance the competing risks of hypoxemia and hyperoxemia.

Read more

Editor's Choice

Tenecteplase improves outcomes in basilar artery occlusion

Intravenous tenecteplase thrombolysis within 24 hours of stroke onset improves functional outcomes versus standard medical treatment in patients with basilar artery occlusion.

Minocycline could improve acute ischemic stroke outcomes

Giving the antibiotic minocycline to patients with acute ischemic stroke within 72 hours of symptom onset significantly improves functional outcomes at 90 days without increasing the risk for adverse events.

Thrombolysis not recommended for central RAO

Tenecteplase thrombolysis is no more effective than aspirin for treating acute central retinal artery occlusion, and is associated with safety concerns.

Recognizing stroke-mimicking NIID

Stroke-like episodes are an important clinical phenotype of neuronal intranuclear inclusion disease, but these cases are prone to misdiagnosis as acute stroke. Explore the most common clinical and imaging features of NIID.

Our tailored content service will keep you up to date…

Receive newsletters curated for the busy specialist by our expert editorial team

Next-generation MRI contrast agents: preparing the field (Link opens in a new window)

New MRI contrast agents are reshaping diagnostic imaging, promising lower gadolinium exposure amid evolving practice guidelines. How can you optimise contrast selection, dosing, and patient care in this rapidly advancing field?

This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window

Case Studies

Recognizing stroke-mimicking NIID

Stroke-like episodes are an important clinical phenotype of neuronal intranuclear inclusion disease, but these cases are prone to misdiagnosis as acute stroke. Explore the most common clinical and imaging features of NIID.

Pediatric AIS: a dual-drug approach

This case study highlights a promising approach for pediatric acute ischemic stroke: ultra-early IV tenecteplase thrombolysis followed by targeted intra-arterial tirofiban to tackle large vessel occlusion.

Dizziness and unsteady walking: could it be HOD?

Hypertrophic olivary degeneration is commonly caused by cerebral infarction. This case indicates that HOD should be considered in patients with a history of brainstem infarction who have new or progressively worsening symptoms.

Episode 21: Moving towards migraine freedom?

Newcomer PACAP could make the difference in migraine control

Anti-CGRP therapy has dramatically improved migraine treatment for many patients since its introduction in 2018. However, 30–40% of patients do not respond adequately to these drugs.

Prof. Messoud Ashina talks to us about PACAP and why targeting this pathway could offer a new future option for such patients.

Prof. Messoud Ashina
Listen now
Podcast

Current Reviews

Patent foramen ovale closure versus medical therapy alone in elderly patients with cryptogenic stroke: a systematic review and meta-analysis

The potential benefit of patent foramen ovale device closure (PFOC) in reducing the risk of recurrent ischemic events such as ischemic stroke (IS) and transient ischemic attack (TIA) among patients with cryptogenic stroke (CS) has been the subject …

From Stroke to Strength: The Role of Exercise in Managing Hypertension and Lipid Profiles

Secondary stroke prevention focuses on managing vascular risk factors such as hypertension, hyperglycemia, and dyslipidemia. However, the impact of exercise training regimens (ETR) on these factors post-stroke remains unclear. We conducted a …

Targeting DNA Damage and Repair Pathways in Cerebral Ischemic Stroke: From Bench to Bedside

Despite advances in reperfusion therapies following cerebral ischemic stroke, effective treatment options remain limited, and achieving optimal outcomes post-revascularization continues to be a significant challenge. Increasing evidences have …

Keynote webinar | Spotlight on sleep in brain health

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
Watch now
Video

CME & eLearning

Next-generation MRI contrast agents: preparing the field (Link opens in a new window)

New MRI contrast agents are reshaping diagnostic imaging, promising lower gadolinium exposure amid evolving practice guidelines. How can you optimize contrast selection, dosing, and patient care in this rapidly advancing field?

This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.

Further Reading

Stroke and transient ischemic attack recurrence after PFO closure in patients with cryptogenic embolism

  • Open Access
  • Stroke
  • Original Article

Stroke is one of the major causes of disability-adjusted life years worldwide and the second most common cause of death in Europe [ 1 ]. In approximately 10% of all strokes, no other evident cause is identified except a patent foramen ovale (PFO) [ …2

Clinical and Radiological Features of Aphasia Caused by Brainstem Infarction: Two Case Reports

Cognitive impairment resulting from cerebellar damage, known as cerebellar cognitive affective syndrome (CCAS), can cause language impairment and aphasia. The disruption of the cerebro-cerebellar pathway is a possible mechanism for CCAS.

Phenotype-Aligned Metabolomics Identifies Plasma Arginine as a Candidate Predictor of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

Delayed cerebral ischemia (DCI) affects approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) survivors and is a leading cause of morbidity and mortality post-aSAH. Current risk assessment relies on radiographic severity scores that …

Clinical, laboratory, and radiological features influencing admission DWI-ASPECTS in stroke patients with middle cerebral artery occlusion undergoing mechanical thrombectomy

  • Open Access
  • Stroke
  • Original Article

The Alberta Stroke Programme Early Computed Tomography Score (ASPECTS) is a widely used, rapid, and practical score for quantifying the extent of early ischemic changes in acute ischemic stroke [ 1 , 2 ]. Several studies showed that ASPECTS is …

Image Credits
Ventilator monitor for patient in ICU/© Taechit / Stock.adobe.com (symbolic image with model), Intravenous injection/© YaroslavKryuchka / Getty Images, Brain model and white capsules/© Ekaterina / stock.adobe.com, Illustration of blood vessels/© ustas / stock.adobe.com, MRI brain scan showing diffusion restriction at the corticomedullary junction in neuronal intranuclear inclusion disease/© 2026, Fondazione Società Italiana di Neurologia, Neurol Sci, Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME, Emergency ambulance transfer/© Ronny / stock.adobe.com, Neurological stenting concept/© freshidea / stock.adobe.com, Close-up of child's hand with IV drip/© Siam / stock.adobe.com (symbolic image with model), Diffusion tensor imaging scans of the head in hypertrophic olivary degeneration/© 2025, Zhuo Qun Li et al, BMC Neurol, Medicine Matters Podcast promo image/© Springer Medizin GmbH, Hand holding illustration of brain on scenic background/© Natali_Mis / Getty Images / iStock