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Open Access 01-12-2021 | ST-Segment Elevation Myocardial Infarction | Research article

In-hospital and 30-day major adverse cardiac events in patients referred for ST-segment elevation myocardial infarction in Dhaka, Bangladesh

Authors: Zubair Akhtar, Mohammad Abdul Aleem, Probir Kumar Ghosh, A. K. M. Monwarul Islam, Fahmida Chowdhury, C. Raina MacIntyre, Ole Fröbert

Published in: BMC Cardiovascular Disorders | Issue 1/2021

Abstract

Background

There is a paucity of data regarding acute phase (in-hospital and 30-day) major adverse cardiac events (MACE) following ST-segment elevation myocardial infarction (STEMI) in Bangladesh. This study aimed to document MACE during the acute phase post-STEMI to provide information.

Methods

We enrolled STEMI patients of the National Institute of Cardiovascular Disease, Dhaka, Bangladesh, from August 2017 to October 2018 and followed up through 30 days post-discharge for MACE, defined as the composite of all-cause death, myocardial infarction, and coronary revascularization. Demographic information, cardiovascular risk factors, and clinical data were registered in a case report form. The Cox proportional hazard model was used for univariate and multivariate analysis to identify potential risk factors for MACE.

Results

A total of 601 patients, mean age 51.6 ± 10.3 years, 93% male, were enrolled. The mean duration of hospital stay was 3.8 ± 2.4 days. We found 37 patients (6.2%) to experience an in-hospital event, and 45 (7.5%) events occurred within the 30 days post-discharge. In univariate analysis, a significantly increased risk of developing 30-day MACE was observed in patients with more than 12 years of formal education, diabetes mellitus, or a previous diagnosis of heart failure. In a multivariate analysis, the risk of developing 30-day MACE was increased in patients with heart failure (hazard ratio = 4.65; 95% CI 1.64–13.23).

Conclusions

A high risk of in-hospital and 30-day MACE in patients with STEMI exists in Bangladesh. Additional resources should be allocated providing guideline-recommended treatment for patients with myocardial infarction in Bangladesh.

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Title: In-hospital and 30-day major adverse cardiac events in patients referred for ST-segment elevation myocardial infarction in Dhaka, Bangladesh
Authors: Zubair Akhtar
Mohammad Abdul Aleem
Probir Kumar Ghosh
A. K. M. Monwarul Islam
Fahmida Chowdhury
C. Raina MacIntyre
Ole Fröbert
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: ST-Segment Elevation Myocardial Infarction
Myocardial Infarction
Heart Failure
Published in: BMC Cardiovascular Disorders / Issue 1/2021
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-021-01896-9

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