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BMC Cardiovascular Disorders
Published in: BMC Cardiovascular Disorders 1/2019

Open Access 01-12-2019 | ST-Segment Elevation Myocardial Infarction | Research article

Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study

Authors: Tongtong Yu, Yundi Jiao, Jia Song, Dongxu He, Jiake Wu, Zhijun Sun, Zhaoqing Sun

Published in: BMC Cardiovascular Disorders | Issue 1/2019

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Abstract

Backgroud

To assess the value of D-dimer and its combination with The Global Registry of Acute Coronary Events (GRACE) score in predicting in-hospital mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).

Methods

In 5923 ACS patients undergoing PCI, the role of D-dimer and the added value of D-dimer to GRACE score for predicting in-hospital mortality were tested.

Results

After multivariable adjustment, D-dimer could significantly predict in-hospital mortality. Also, it could significantly improve the prognostic performance of GRACE score (C-statistic: z = 2.269, p = 0.023; IDI: 0.016, p = 0.032; NRI: 0.291, p = 0.035).

Conclusion

In patients with ACS undergoing PCI, D-dimer was an independent predictor of in-hospital death. It could also improve the prognostic performance of GRACE score.
Appendix
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Metadata
Title
Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study
Authors
Tongtong Yu
Yundi Jiao
Jia Song
Dongxu He
Jiake Wu
Zhijun Sun
Zhaoqing Sun
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2019
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-019-1239-4

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