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Investigational New Drugs

Issue 3/2009

Content (14 Articles)

PRECLINICAL STUDIES

N-benzoxazol-2-yl-N′-1-(isoquinolin-3-yl-ethylidene)-hydrazine, a novel compound with antitumor activity, induces radicals and dissipation of mitochondrial membrane potential

Johann Hofmann, Johnny Easmon, Gerhard Puerstinger, Gottfried Heinisch, Marcel Jenny, Alexander A. Shtil, Martin Hermann, Daniele F. Condorelli, Salvatore Sciré, Giuseppe Musumarra

PRECLINICAL STUDIES

Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis

Selvaraj Aranganathan, Jayabal Panneer Selvam, Namasivayam Nalini

PRECLINICAL STUDIES

Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice

Sattu Kamaraj, Gopalakrishnan Ramakrishnan, Pandi Anandakumar, Sundaram Jagan, Thiruvengadam Devaki

PRECLINICAL STUDIES

Antitumor activity of a novel series of α-aryloxy-α-methylhydrocinnamic acid derivatives as PPAR gamma agonists against a panel of human cancer cell lines

Xishan Xiong, Yangliang Ye, Lili Fu, Bing Dai, Jieqiong Liu, Jieshuang Jia, Jing Tang, Lin Li, Li Wang, Jianhua Shen, Changlin Mei

Preclinical Studies

Silymarin attenuated mast cell recruitment thereby decreased the expressions of matrix metalloproteinases-2 and 9 in rat liver carcinogenesis

Gopalakrishnan Ramakrishnan, Sundaram Jagan, Sattu Kamaraj, Pandi Anandakumar, Thiruvengadam Devaki

PRECLINICAL STUDIES

Antiviral activity of cidofovir against telomerase-specific replication-selective oncolytic adenovirus, OBP-301 (Telomelysin)

Masaaki Ouchi, Hitoshi Kawamura, Yasuo Urata, Toshiyoshi Fujiwara

PRECLINICAL STUDIES

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

G. Harish Kumar, K.V.P. Chandra Mohan, A. Jagannadha Rao, S. Nagini

PHASE I STUDIES

Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer

Michael Michael, Peter Gibbs, Robert Smith, Alex Godwood, Stuart Oliver, Niall Tebbutt

PHASE I STUDIES

Phase I trial of neoadjuvant chemoradiotherapy (CRT) with capecitabine and weekly irinotecan followed by laparoscopic total mesorectal excision (LTME) in rectal cancer patients

Lisardo Ugidos, Salvadora Delgado, Carlos Conill, Angels Ginés, Rosa Gallego, Juan Ramón Ayuso, Rosa Miquel, Monica Tosca, Antonio de Lacy, Antoni Castells, Joan Maurel

PHASE II STUDIES

A phase II study of S-1 plus irinotecan and oxaliplatin in heavily-treated patients with metastatic colorectal cancer

Sun Young Kim, Yong Sang Hong, Byung Chang Kim, Ji Won Park, Hyo Seong Choi, Seung-Yong Jeong, Dae Yong Kim, Chang Won Hong, Dae Kyung Sohn, Kyung Hae Jung

PHASE II STUDIES

A phase II trial of chemoradiation therapy with weekly oxaliplatin and protracted infusion of 5-fluorouracil for esophageal cancer

Bryan H. Burmeister, Euan T. Walpole, Nancy D’Arcy, Elizabeth A. Burmeister, Sharon Cox, Damien B. Thomson, Jennifer A. Harvey, B. Mark Smithers

Short Report

Enhancement of the action of the antivascular drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA; ASA404) by non-steroidal anti-inflammatory drugs

L.-C. Steve Wang, Lai-Ming Ching, James W. Paxton, Philip Kestell, Rachel Sutherland, Li Zhuang, Bruce C. Baguley

SHORT REPORT

Rhinitis and epistaxis in patients treated by anti-angiogenic therapy

V. Prulière-Escabasse, E. Escudier, R. Balheda, J. C. Soria, A. Coste, C. Massard

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine