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Investigational New Drugs

Issue 2/2009

Content (12 Articles)

PRECLINICAL STUDIES

Sulfinosine enhances doxorubicin efficacy through synergism and by reversing multidrug resistance in the human non-small cell lung carcinoma cell line (NCI-H460/R)

Milica Pešić, Tijana Andjelković, Jasna Banković, Ivanka D. Marković, Ljubiša Rakić, Sabera Ruždijić

PRECLINICAL STUDIES

Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth

Masaharu Hazawa, Koji Wada, Kenji Takahashi, Takao Mori, Norio Kawahara, Ikuo Kashiwakura

PRECLINICAL STUDIES

Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer

Manon Buijs, Josephina A. Vossen, Jean-Francois H. Geschwind, Takayoshi Ishimori, James M. Engles, Obele Acha-Ngwodo, Richard L. Wahl, Mustafa Vali

PRECLINICAL STUDIES

In vitro cytotoxic activity of tri-n-butyltin(IV)lupinylsulfide hydrogen fumarate (IST-FS 35) and preliminary antitumor activity in vivo

Angela Alama, Maurizio Viale, Michele Cilli, Cristina Bruzzo, Federica Novelli, Bruno Tasso, Fabio Sparatore

PHASE I STUDIES

Synthesis and antiproliferative activity of substituted diazaspiro hydantoins: a structure–activity relationship study

Ananda Kumar C. S., S. B. Benaka Prasad, K. Vinaya, S. Chandrappa, N. R. Thimmegowda, S. R. Ranganatha, Sanjay Swarup, K. S. Rangappa

Phase I Studies

Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820

Ron J. Keizer, Miren K. Zamacona, Mendel Jansen, David Critchley, Jantien Wanders, Jos H. Beijnen, Jan H. M. Schellens, Alwin D. R. Huitema

PHASE I STUDIES

Phase I study of capecitabine in combination with cisplatin and irinotecan in patients with advanced solid malignancies

H. Sayar, Z. Shen, S. J. Lee, M. Royce, I. Rabinowitz, F. Lee, H. Smith, S. Eberhardt, A. Maestas, H. Lu, C. Verschraegen

Phase II Studies

A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer

Elaina M. Gartner, Kent A. Griffith, Quintin Pan, George J. Brewer, Gwen F. Henja, Sofia D. Merajver, Mark M. Zalupski

SHORT REPORT

Trastuzumab induces gastrointestinal side effects in HER2-overexpressing breast cancer patients

Noor Al-Dasooqi, Joanne M. Bowen, Rachel J. Gibson, Thomas Sullivan, Jude Lees, Dorothy M. Keefe

Open Access SHORT REPORT

Level of HER2/neu gene amplification as a predictive factor of response to trastuzumab-based therapy in patients with HER2-positive metastatic breast cancer

Giuseppe Gullo, Daniela Bettio, Valter Torri, Giovanna Masci, Piermario Salvini, Armando Santoro

SHORT REPORT

Bowel perforation in non-small cell lung cancer after bevacizumab therapy

Elisabeth Schellhaas, Christoph Loddenkemper, Alexander Schmittel, Heinz-J. Buhr, Uwe Pohlen

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine