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01-04-2017 | Review

Sepsis: frontiers in supportive care, organisation and research

Authors: Anders Perner, Andrew Rhodes, Bala Venkatesh, Derek C. Angus, Ignacio Martin-loeches, Jean-Charles Preiser, Jean-Louis Vincent, John Marshall, Konrad Reinhart, Michael Joannidis, Steven M. Opal

Published in: Intensive Care Medicine | Issue 4/2017

Abstract

Because of its high incidence and clinical complexity, sepsis is a major challenge to clinicians and researchers and a global burden to healthcare systems and society. Despite recent progress, short- and long-term morbidity, mortality and costs remain high in both developed and developing countries. Thus, further improvements in supportive interventions and organisation of care are likely to have a substantial impact upon global health. In this narrative review, invited experts describe the challenges and progress to be made in sepsis research and care in the near future. We focus on supportive care (pulmonary, endocrine, renal, and nutritional support, mediator modulation and precision medicine), organisational themes (guidelines, outcome measures and stakeholder involvement) and clinical research as key areas to improving the care and outcomes of patients with sepsis.

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Title: Sepsis: frontiers in supportive care, organisation and research
Authors: Anders Perner
Andrew Rhodes
Bala Venkatesh
Derek C. Angus
Ignacio Martin-loeches
Jean-Charles Preiser
Jean-Louis Vincent
John Marshall
Konrad Reinhart
Michael Joannidis
Steven M. Opal
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 4/2017
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-017-4677-4

At a glance: The STEP trials

Springer Medicine

Sepsis: frontiers in supportive care, organisation and research

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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Some remaining important questions after LUNG SAFE

New developments in the provision of family-centered care in the intensive care unit

Right–left ventricular interdependence: a promising predictor of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory cardiogenic shock

Lung–brain cross talk in the critically ill