Published in:
Open Access
01-12-2022 | SARS-CoV-2 | Letter to the Editor
Longitudinal assessment of systemic steroid therapy on hyperinflammatory endothelial biomarker profiles and serology responses of COVID-19 patients
Authors:
Jonathan T. Sims, Ching-Yun Chang, Josh Poorbaugh, Montanea Daniels, Stephanie L. Beasley, Lin Zhang, George H. Rodgers, Fabio Lena, Leonardo G. Lacerenza, Bruno Sposato, Annabelle Dupont, Sophie Susen, Giacomo Casalini, Mario Corbellino, Justin Stebbing, Venkatesh Krishnan
Published in:
Journal of Translational Medicine
|
Issue 1/2022
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Excerpt
This first of its kind study provides objective context to the potential mechanism of action of corticosteroid use by connecting inflammatory biomarkers to IgG levels for the SARS-CoV-2 spike protein antigens and neutralization of ACE2 binding within patients across 3 institutions from Italy and France who received corticosteroids (dexamethasone, n = 5, or prednisolone, n = 1) or usual standard of care (SOC, n = 22) therapy. The median Ordinal Scale (WHO) upon admission was OS-5 and no difference in days from symptom onset or Ordinal scale at study entry was observed between these 2 groups (Additional file
1: Table S1, Fig. S1). Utilizing Olink multiplex technology and IL-19 ELISA, we assessed 185 analytes in the circulation of COVID-19 patients along with Luminex-based measurement of 10 immunoglobulins, including neutralization assessment (Additional file
2). …
