Identification of IGF1R mutation as a novel predictor of efficacious immunotherapy in melanoma

Excerpt

Insulin-like growth factor-1 receptor (IGF-1R), a member of the tyrosine protein kinase receptor family, displays potent anti-apoptotic and pro-survival capacities and plays a key role in malignant transformation [1]. Previous studies revealed IGF1R-mediated resistance to BRAF and MEK inhibitors in BRAF-mutant melanoma [2]. However, other research indicated that IGF1R is closely connected with high degrees of tumor infiltrates and some immune-related gene expression, which showed the potential of IGF1R in pan-cancer immunotherapy [3]. Therefore, exploring the role of IGF1R in melanoma immunotherapy may provide an alternative treatment option for target-resistant melanoma. To the best of our knowledge, no study has reported the efficacy of immunotherapy in melanoma with IGF1R mutation. …