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Pediatric Nephrology

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01-04-2013 | Original Article

Risk factors for urinary stones in healthy schoolchildren with and without a family history of nephrolithiasis

Authors: Concepción Sáez-Torres, Félix Grases, Dolores Rodrigo, Ana María García-Raja, Cristina Gómez, Guillem Frontera

Published in: Pediatric Nephrology | Issue 4/2013

Abstract

Background

The prevalence of lithiasis is increasing at all ages. This study aimed to assess the crystallization risk in urine from healthy school children and to determine urinary parameters that are most associated with it.

Methods

Urine samples were obtained from 184 children aged 5–12 years: a spot sample collected in the afternoon, and a 12-h overnight sample. Information was obtained regarding family histories of lithiasis. Urine volume, pH, and biochemical parameters of stone risk were measured. Crystallization risk was defined by the presence of specific urine conditions that had previously been associated with stone formation in vitro.

Results

Crystallization risk was observed in 15 % of spot urine samples and 54 % of 12-h samples. Metabolic abnormalities and a low urinary volume were more frequently detected in children with crystallization risk. Calcium excretion and calcium/citrate ratio were higher in children with a family history of lithiasis.

Conclusions

We observed a high prevalence of crystallization risk in urine, especially in children with a family history of the disease. Low urinary volume was the factor most associated with increased risk. Adequate fluid intake at an early age may be a simple and effective measure to reduce the incidence of nephrolithiasis.

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Title: Risk factors for urinary stones in healthy schoolchildren with and without a family history of nephrolithiasis
Authors: Concepción Sáez-Torres
Félix Grases
Dolores Rodrigo
Ana María García-Raja
Cristina Gómez
Guillem Frontera
Publication date: 01-04-2013
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 4/2013
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2368-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Risk factors for urinary stones in healthy schoolchildren with and without a family history of nephrolithiasis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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