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Pediatric Nephrology
Published in: Pediatric Nephrology 4/2013

01-04-2013 | Review

Vitamin D and inflammation

Author: Uwe Querfeld

Published in: Pediatric Nephrology | Issue 4/2013

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Abstract

Recent studies have provided evidence for an important role of vitamin D deficiency in the pathogenesis of cardiovascular disease (CVD) in the general population, and of an association with markers of inflammation. Vitamin D deficiency, defined by low serum levels of 25-hydroxyvitamin D, is especially prevalent in patients with chronic kidney disease (CKD). Chronic low-grade inflammation is a hallmark of CKD and has been disclosed as one important factor contributing to the progression of CKD and a high cardiovascular comorbidity. This review highlights clinical and experimental studies that could potentially explain a link between vitamin D and inflammation. Whether correction of vitamin D deficiency has beneficial effects on markers of inflammation and cardiovascular outcome should be investigated by controlled clinical trials.
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Metadata
Title
Vitamin D and inflammation
Author
Uwe Querfeld
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
Pediatric Nephrology / Issue 4/2013
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-012-2377-4

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