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Pediatric Nephrology
Published in: Pediatric Nephrology 10/2007

Open Access 01-10-2007 | Review

Pathophysiology of hypercalciuria in children

Authors: Tarak Srivastava, Uri S. Alon

Published in: Pediatric Nephrology | Issue 10/2007

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Abstract

Urinary excretion of calcium is the result of a complex interplay between three organs—namely, the gastrointestinal tract, bone, and kidney—which is finely orchestrated by multiple hormones. Hypercalciuria is believed to be a polygenic trait and is influenced significantly by diet. This paper briefly reviews calcium handling by the renal tubule in normal and in hereditary disorders as it relates to the pathophysiology of hypercalciuria. The effects of dietary sodium, potassium, protein, calcium, and phosphate on calcium excretion, and the association of hypercalciuria with bone homeostasis is discussed, leading to recommendations on means to address excessive urinary calcium excretion.
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Metadata
Title
Pathophysiology of hypercalciuria in children
Authors
Tarak Srivastava
Uri S. Alon
Publication date
01-10-2007
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 10/2007
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-007-0482-6

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