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Drugs
Published in: Drugs 10/2021

Open Access 01-07-2021 | Primary Sclerosing Cholangitis | Review Article

Cholestatic Liver Disease: Current Treatment Strategies and New Therapeutic Agents

Authors: Sho Hasegawa, Masato Yoneda, Yusuke Kurita, Asako Nogami, Yasushi Honda, Kunihiro Hosono, Atsushi Nakajima

Published in: Drugs | Issue 10/2021

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Abstract

Cholestatic liver disease is a disease that causes liver damage and fibrosis owing to bile stasis. It is represented by primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), but the pathophysiological pathways that cause bile stasis in both diseases are different. The pathogenesis of the disease is still unclear, although autoimmune mechanisms have been postulated and partially elucidated. Although the disease may progress slowly with only mild liver dysfunction, it may progress to liver cirrhosis or liver failure, which require liver transplantation. As a medical treatment, ursodeoxycholic acid is widely used for PBC and has proved to be very effective against disease progression in cases of PBC. On the other hand, its efficacy is limited in cases of PSC, and the research and development of various drugs are underway. Furthermore, the clinical course of both diseases is quite variable, making the design of clinical trials fairly difficult. In this review, we present the general natural history of PBC and PSC, and provide information on the latest drug therapies currently available and those that are under investigation.
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Metadata
Title
Cholestatic Liver Disease: Current Treatment Strategies and New Therapeutic Agents
Authors
Sho Hasegawa
Masato Yoneda
Yusuke Kurita
Asako Nogami
Yasushi Honda
Kunihiro Hosono
Atsushi Nakajima
Publication date
01-07-2021
Publisher
Springer International Publishing
Published in
Drugs / Issue 10/2021
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-021-01545-7

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