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01-02-2020 | Primary Immunodeficiency | Letter to Editor

Disseminated Pneumocystis jirovecii Infection with Osteomyelitis in a Patient with CTLA-4 Haploinsufficiency

Authors: Aminaa E. Siddiqi, Anne Y. Liu, Gregory W. Charville, Christian A. Kunder, Gulbu Uzel, Amir A. Sadighi Akha, Jean Oak, Beth Martin, Joshua Sacha, David B. Lewis, Yael Gernez

Published in: Journal of Clinical Immunology | Issue 2/2020

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To the Editor …

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Cohen OJ, Stoeckle MY. Extrapulmonary Pneumocystis carinii infections in the acquired immunodeficiency syndrome. Arch Intern Med. 1991;151(6):1205–14.CrossRef

Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, et al. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science. 2014;345(6204):1623–7.CrossRef

Schubert D, Bode C, Kenefeck R, Hou TZ, Wing JB, Kennedy A, et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med. 2014;20(12):1410–6.CrossRef

Schwab C, Gabrysch A, Olbrich P, Patino V, Warnatz K, Wolff D, et al. Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects. J Allergy Clin Immunol. 2018;142(6):1932–46.CrossRef

Yarmohammadi H, Cunningham-Rundles C. Idiopathic CD4 lymphocytopenia: pathogenesis, etiologies, clinical presentations and treatment strategies. Ann Allergy Asthma Immunol. 2017;119(4):374.CrossRef

Title: Disseminated Pneumocystis jirovecii Infection with Osteomyelitis in a Patient with CTLA-4 Haploinsufficiency
Authors: Aminaa E. Siddiqi
Anne Y. Liu
Gregory W. Charville
Christian A. Kunder
Gulbu Uzel
Amir A. Sadighi Akha
Jean Oak
Beth Martin
Joshua Sacha
David B. Lewis
Yael Gernez
Publication date: 01-02-2020
Publisher: Springer US
Keywords: Primary Immunodeficiency
Opportunistic Infection
Immunodeficiency
Lymphopenia
Human Immunodeficiency Virus
Osteomyelitis
Published in: Journal of Clinical Immunology / Issue 2/2020
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-020-00748-z

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