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Clinical and Translational Medicine
Published in: Clinical and Translational Medicine 1/2014

Open Access 01-12-2014 | Review

Pluripotent muse cells derived from human adipose tissue: a new perspective on regenerative medicine and cell therapy

Authors: Ariel A Simerman, Daniel A Dumesic, Gregorio D Chazenbalk

Published in: Clinical and Translational Medicine | Issue 1/2014

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Abstract

In 2010, Multilineage Differentiating Stress Enduring (Muse) cells were introduced to the scientific community, offering potential resolution to the issue of teratoma formation that plagues both embryonic stem (ES) and induced pluripotent (iPS) stem cells. Isolated from human bone marrow, dermal fibroblasts, adipose tissue and commercially available adipose stem cells (ASCs) under severe cellular stress conditions, Muse cells self-renew in a controlled manner and do not form teratomas when injected into immune-deficient mice. Furthermore, Muse cells express classic pluripotency markers and differentiate into cells from the three embryonic germ layers both spontaneously and under media-specific induction. When transplanted in vivo, Muse cells contribute to tissue generation and repair. This review delves into the aspects of Muse cells that set them apart from ES, iPS, and various reported adult pluripotent stem cell lines, with specific emphasis on Muse cells derived from adipose tissue (Muse-AT), and their potential to revolutionize the field of regenerative medicine and stem cell therapy.
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Metadata
Title
Pluripotent muse cells derived from human adipose tissue: a new perspective on regenerative medicine and cell therapy
Authors
Ariel A Simerman
Daniel A Dumesic
Gregorio D Chazenbalk
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2014
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/2001-1326-3-12

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