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Clinical and Translational Medicine
Published in: Clinical and Translational Medicine 1/2014

Open Access 01-12-2014 | Review

Clinical significance of macrophage phenotypes in cardiovascular disease

Authors: Heather J Medbury, Helen Williams, John P Fletcher

Published in: Clinical and Translational Medicine | Issue 1/2014

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Abstract

The emerging understanding of macrophage subsets and their functions in the atherosclerotic plaque has led to the consensus that M1 macrophages are pro-atherogenic while M2 macrophages may promote plaque stability, primarily though their tissue repair and anti-inflammatory properties. As such, modulating macrophage function to promote plaque stability is an exciting therapeutic prospect. This review will outline the involvement of the different macrophage subsets throughout atherosclerosis progression and in models of regression. It is evident that much of our understanding of macrophage function comes from in vitro or small animal models and, while such knowledge is valuable, we have much to learn about the roles of the macrophage subsets in the clinical setting in order to identify the key pathways to target to possibly promote plaque stability.
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Metadata
Title
Clinical significance of macrophage phenotypes in cardiovascular disease
Authors
Heather J Medbury
Helen Williams
John P Fletcher
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2014
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/s40169-014-0042-1

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