Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 2/2019

01-04-2019 | Editorial

Phase dyssynchrony and 123I-meta-iodobenzylguanidine innervation imaging towards standardization

Authors: Kenichi Nakajima, MD, PhD, Koichi Okuda, PhD, Hein J. Verberne, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 2/2019

Login to get access

Excerpt

Over the last decades, semi-quantitative analysis has become crucial in the assessment of myocardial perfusion scintigraphy. Through widely available software packages, electrocardiographically (ECG) gated myocardial perfusion single-photon emission computed tomography (SPECT) quantitative parameters of left ventricular (LV) function are easily obtainable. These software algorithms have increased worldwide consistency and improved quality of myocardial perfusion scintigraphy in the assessment of the total ischemic burden, left ventricular (LV) volumes, and left ventricular ejection fraction (LVEF). In general, these software algorithms have standardized the interpretation of ECG gated myocardial perfusion SPECT. However, for other parameters of left ventricular function such as phase analysis of ECG gated myocardial perfusion SPECT and regional analysis of cardiac sympathetic imaging with 123I-meta-iodobenzylguanidine (123I-mIBG), standardization is still not reached. This lack of standardization hampers the widespread clinical use of the potentially very valuable parameters obtained with phase analysis and 123I-mIBG quantitation methods. …
Literature
1.
Verberne HJ. Assessment of cardiac sympathetic innervation with 123I-mIBG SPECT comes to life: Need for standardization! Eur Heart J Cardiovasc Imaging 2016;17:391-2.CrossRefPubMed
2.
Nakajima K, Verschure DO, Okuda K, Verberne HJ. Standardization of 123I-meta-iodobenzylguanidine myocardial sympathetic activity imaging: Phantom calibration and clinical applications. Clin Transl Imaging 2017;5:255-63.CrossRefPubMedPubMedCentral
3.
Nakajima K, Yamada M. 123I-meta-iodobenzylguanidine sympathetic imaging: Standardization and application to neurological diseases. Chonnam Med J 2016;52:145-50.CrossRefPubMedPubMedCentral
4.
Verberne HJ, Feenstra C, de Jong WM, Somsen GA, van Eck-Smit BL, Busemann Sokole E. Influence of collimator choice and simulated clinical conditions on 123I-MIBG heart/mediastinum ratios: A phantom study. Eur J Nucl Med Mol Imaging 2005;32:1100-7.CrossRefPubMed
5.
Nakajima K, Okuda K, Yoshimura M, Matsuo S, Wakabayashi H, Imanishi Y, Kinuya S. Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations. J Nucl Cardiol 2014;21:970-8.CrossRefPubMedPubMedCentral
6.
7.
Bellevre D, Manrique A, Legallois D, Bross S, Baavour R, Roth N, Blaire T, Desmonts C, Bailliez A, Agostini D. First determination of the heart-to-mediastinum ratio using cardiac dual isotope 123I-MIBG / 99mTc-tetrofosmin) CZT imaging in patients with heart failure: The ADRECARD study. Eur J Nucl Med Mol Imaging 2015;42:1912-9.CrossRefPubMed
8.
Blaire T, Bailliez A, Ben Bouallegue F, Bellevre D, Agostini D, Manrique A. Determination of the heart-to-mediastinum ratio of 123I-MIBG uptake using dual-isotope (123I-MIBG/99mTc-tetrofosmin) multi-pinhole CZT SPECT in patients with heart failure. J Nucl Med 2017. doi:10.​2967/​jnumed.​117.​194373.CrossRefPubMed
9.
10.
Boogers MJ, Borleffs CJ, Henneman MM, van Bommel RJ, van Ramshorst J, Boersma E, Dibbets-Schneider P, Stokkel MP, van der Wall EE, Schalij MJ, Bax JJ. Cardiac sympathetic denervation assessed with 123-iodine metaiodobenzylguanidine imaging predicts ventricular arrhythmias in implantable cardioverter-defibrillator patients. J Am Coll Cardiol 2010;55:2769-77.CrossRefPubMed
11.
Clements IP, Kelkar AA, Garcia EV, Butler J, Chen J, Folks R, Jacobson AF. Prognostic significance of (123)I-mIBG SPECT myocardial imaging in heart failure: Differences between patients with ischaemic and non-ischaemic heart failure. Eur Heart J Cardiovasc Imaging 2016;17:384-90.CrossRefPubMed
12.
Travin MI, Henzlova MJ, van Eck-Smit BL, Jain D, Carrio I, Folks RD, Garcia EV, Jacobson AF, Verberne HJ. Assessment of I-mIBG and Tc-tetrofosmin single-photon emission computed tomographic images for the prediction of arrhythmic events in patients with ischemic heart failure: Intermediate severity innervation defects are associated with higher arrhythmic risk. J Nucl Cardiol 2016;24:377-91.CrossRefPubMed
13.
14.
Nakajima K, Matsumoto N, Kasai T, Matsuo S, Kiso K, Okuda K. Normal values and standardization of parameters in nuclear cardiology: Japanese Society of Nuclear Medicine working group database. Ann Nucl Med 2016;30:188-99.CrossRefPubMedPubMedCentral
15.
Gimelli A, Liga R, Menichetti F, Soldati E, Bongiorni MG, Marzullo P. Interactions between myocardial sympathetic denervation and left ventricular mechanical dyssynchrony: A CZT analysis. J Nucl Cardiol 2017. doi:10.​1007/​s12350-017-1036-3.CrossRefPubMed
16.
Chen J, Folks RD, Verdes L, Manatunga DN, Jacobson AF, Garcia EV. Quantitative I-123 mIBG SPECT in differentiating abnormal and normal mIBG myocardial uptake. J Nucl Cardiol 2012;19:92-9.CrossRefPubMed
17.
Chen J, Garcia EV, Folks RD, Cooke CD, Faber TL, Tauxe EL, Iskandrian AE. Onset of left ventricular mechanical contraction as determined by phase analysis of ECG-gated myocardial perfusion SPECT imaging: Development of a diagnostic tool for assessment of cardiac mechanical dyssynchrony. J Nucl Cardiol 2005;12:687-95.CrossRefPubMed
18.
Gimelli A, Liga R, Giorgetti A, Favilli B, Pasanisi EM, Marzullo P. Determinants of left ventricular mechanical dyssynchrony in patients submitted to myocardial perfusion imaging: A cardiac CZT study. J Nucl Cardiol 2016;23:728-36.CrossRefPubMed
19.
Boogers MM, Van Kriekinge SD, Henneman MM, Ypenburg C, Van Bommel RJ, Boersma E, Dibbets-Schneider P, Stokkel MP, Schalij MJ, Berman DS, Germano G, Bax JJ. Quantitative gated SPECT-derived phase analysis on gated myocardial perfusion SPECT detects left ventricular dyssynchrony and predicts response to cardiac resynchronization therapy. J Nucl Med 2009;50:718-25.CrossRefPubMed
20.
Van Kriekinge SD, Nishina H, Ohba M, Berman DS, Germano G. Automatic global and regional phase analysis from gated myocardial perfusion SPECT imaging: Application to the characterization of ventricular contraction in patients with left bundle branch block. J Nucl Med 2008;49:1790-7.CrossRefPubMed
21.
Nakajima K, Okuda K, Matsuo S, Kiso K, Kinuya S, Garcia EV. Comparison of phase dyssynchrony analysis using gated myocardial perfusion imaging with four software programs: Based on the Japanese Society of Nuclear Medicine working group normal database. J Nucl Cardiol 2016;24:611-21.CrossRefPubMedPubMedCentral
22.
23.
Okuda K, Nakajima K, Matsuo S, Kashiwaya S, Yoneyama H, Shibutani T, Onoguchi M, Hashimoto M, Kinuya S. Comparison of diagnostic performance of four software packages for phase dyssynchrony analysis in gated myocardial perfusion SPECT. EJNMMI Res. 2017;7:27.CrossRefPubMedPubMedCentral
Metadata
Title
Phase dyssynchrony and 123I-meta-iodobenzylguanidine innervation imaging towards standardization
Authors
Kenichi Nakajima, MD, PhD
Koichi Okuda, PhD
Hein J. Verberne, MD, PhD
Publication date
01-04-2019
Publisher
Springer International Publishing
Published in
Journal of Nuclear Cardiology / Issue 2/2019
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-017-1069-7

Other articles of this Issue 2/2019

Journal of Nuclear Cardiology 2/2019 Go to the issue

Images that Teach

Anti-inflammatory effect of statin in coronary aneurysms late after Kawasaki disease

Original Article

Corrected coronary opacification decrease from coronary computed tomography angiography: Validation with quantitative 13N-ammonia positron emission tomography

History Corner

Hal O. Anger, DSc (hon) (1920-2005)

Original Article

Improved diagnosis of the number of stenosed coronary artery vessels by segmentation with scatter and photo-peak window data for attenuation correction in myocardial perfusion SPECT

Original Article

Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study

Editorial

Early post-STEMI PET, a judicious investment?

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits