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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 9/2005

01-09-2005 | Original Article

Influence of collimator choice and simulated clinical conditions on 123I-MIBG heart/mediastinum ratios: a phantom study

Authors: Hein J. Verberne, Christel Feenstra, W. Matthijs de Jong, G. Aernout Somsen, Berthe L. F. van Eck-Smit, Ellinor Busemann Sokole

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2005

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Abstract

Purpose

123I presents imaging problems owing to high-energy photon emission. We investigated the influence of collimators on 123I-MIBG heart/mediastinum ratios (H/M ratios). Secondly, we assessed the influence on H/M ratios of different activity concentrations, simulating clinical conditions. Thirdly, the value of scatter correction was assessed.

Methods

The AGATE cardiac phantom was filled with 123I in three sequential conditions: A, heart and mediastinal activity; B, adding lung activity; and C, adding liver activity (protocol I). In protocol II, myocardium and liver were filled with different activities ranging from low to high. For each condition, static anterior planar and single-photon emission computed tomography studies were acquired on a Siemens e.cam (SI) and a General Electric Millennium VG (GE) system, using low-energy high-resolution and medium-energy (ME) collimators for protocol I and only ME collimators for protocol II . For the SI camera, a triple energy window (TEW) scatter correction was applied.

Results

Planar H/M ratios were influenced by scatter and septal penetration from increasing amounts of liver activity. These effects were less pronounced for ME collimators. Although the TEW scatter correction increased ratios overall, TEW correction did not improve the relative differences between the ratios. TEW correction therefore does not add any benefit to obtain an accurate reflection of myocardial activity concentrations.

Conclusion

For straightforward implementation of semi-quantitative 123I-MIBG myocardial studies, we recommend the use of ME collimators without scatter correction.
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Metadata
Title
Influence of collimator choice and simulated clinical conditions on 123I-MIBG heart/mediastinum ratios: a phantom study
Authors
Hein J. Verberne
Christel Feenstra
W. Matthijs de Jong
G. Aernout Somsen
Berthe L. F. van Eck-Smit
Ellinor Busemann Sokole
Publication date
01-09-2005
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2005
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-005-1810-3

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