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Child's Nervous System

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Open Access 01-12-2020 | Perinatal Asphyxia | Original Article

Biomarkers in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia

Authors: Barbara Michniewicz, Dawid Szpecht, Anna Sowińska, Rafał Sibiak, Marta Szymankiewicz, Janusz Gadzinowski

Published in: Child's Nervous System | Issue 12/2020

Abstract

Purpose

The aim of the presented study was to evaluate the differences between selected biochemical markers in infants with moderate or severe hypoxic-ischemic encephalopathy (HIE) and their impact on patient prognosis.

Methods

A total of 57 cooled newborns were divided into groups according to Sarnat staging of HIE (A, moderate vs. B, severe). The differences between groups were evaluated depending on the mode of delivery, pregnancy and labor complications, gestational age at birth, birth weight, and Apgar score at 1.3 and 5 min. The differences in biochemical biomarkers of HIE (pH, base excess, serum lactate) as well as biomarkers of hepatic injury (aspartate transaminase, (AST), alanine transaminase (ALT), prothrombin time (PT), and activated partial thromboplastin time (APTT)), kidney failure (creatinine, urea), myocardial injury (troponin T (TnT)), levels of fibrinogen, and platelet counts were also examined. Univariate Kaplan-Meier method was used for survival analyses.

Results

The biomarker levels in severe HIE newborns compared with moderate were as follows: pH (7.10 vs. 6.99), serum lactate (22.50 vs. 17.00 mg/dL), AST (109.50 vs. 270.55 IU/L), ALT (27.30 vs. 108.05 IU/L), PT (17.00 vs. 44.20 s), APTT (47.75 vs. 47.90 s), TnT (0.22 vs. 0.85 ng/mL), creatinine (0.68 vs. 1.15 mg/dL), urea (44.55 vs. 73.30 mg/dL), and fibrinogen (1.65 vs. 1.90 mg/dL). Survival analyses showed significantly reduced survival for severe HIE infants (75%) vs. moderate HIE (100%).

Conclusion

In conclusion, the severity of HIE can be evaluated based on selected markers; however, their levels do not correspond with future prognosis of newborns.

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Title: Biomarkers in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia
Authors: Barbara Michniewicz
Dawid Szpecht
Anna Sowińska
Rafał Sibiak
Marta Szymankiewicz
Janusz Gadzinowski
Publication date: 01-12-2020
Publisher: Springer Berlin Heidelberg
Keywords: Perinatal Asphyxia
Encephalopathy
Biomarkers
Published in: Child's Nervous System / Issue 12/2020
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-020-04645-z

At a glance: The STEP trials

Springer Medicine

Biomarkers in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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