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Cancer Cell International
Published in: Cancer Cell International 1/2020

01-12-2020 | Pancreatectomy | Primary research

The prognostic value of modified Glasgow Prognostic Score in pancreatic cancer: a meta-analysis

Authors: Huan Zhang, Dianyun Ren, Xin Jin, Heshui Wu

Published in: Cancer Cell International | Issue 1/2020

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Abstract

Background

Several studies were conducted to explore the prognostic value of modified Glasgow Prognostic Score (mGPS) in pancreatic cancer, which reported contradictory results. The purpose of this meta-analysis was to summarize and further investigate the correlation between mGPS and overall survival (OS) in pancreatic cancer.

Methods

A systematic literature search was performed in PubMed, EMBASE, ISI Web of Science, Cochrane library databases and OVID to identify eligible studies published from Jan 1, 2011 to June 20, 2020. Pooled hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were used to detect the prognostic significance of mGPS in patients with pancreatic cancer.

Results

A total of 222 non-repetitive studies were identified, and 20 related studies that explored the association between survival outcomes and mGPS in pancreatic cancer patients were finally enrolled in this meta-analysis. The results showed a significant correlation between high level of mGPS and poor OS (HR = 1.50, 95% CI 1.20–1.89, P < 0.0001). Similar results were observed in the subgroup analyses based on the treatment regimen and research region.

Conclusions

Our study suggested the close association between poor prognosis and high level of mGPS, which will be helpful for future clinical applications in patients with pancreatic cancer.
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Metadata
Title
The prognostic value of modified Glasgow Prognostic Score in pancreatic cancer: a meta-analysis
Authors
Huan Zhang
Dianyun Ren
Xin Jin
Heshui Wu
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01558-4

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