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Cancer Cell International
Published in: Cancer Cell International 1/2020

01-12-2020 | Metastasis | Review

Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review

Authors: Houssam Al-Koussa, Nour El Mais, Hiba Maalouf, Ralph Abi-Habib, Mirvat El-Sibai

Published in: Cancer Cell International | Issue 1/2020

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Abstract

Arginine is a semi essential amino acid that is used in protein biosynthesis. It can be obtained from daily food intake or synthesized in the body through the urea cycle using l-citrulline as a substrate. Arginine has a versatile role in the body because it helps in cell division, wound healing, ammonia disposal, immune system, and hormone biosynthesis. It is noteworthy that l-arginine is the precursor for the biosynthesis of nitric oxide (NO) and polyamines. In the case of cancer cells, arginine de novo synthesis is not enough to compensate for their high nutritional needs, forcing them to rely on extracellular supply of arginine. In this review, we will go through the importance of arginine deprivation as a novel targeting therapy by discussing the different arginine deprivation agents and their mechanism of action. We will also focus on the factors that affect cell migration and on the influence of arginine on metastases through polyamine and NO.
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Metadata
Title
Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review
Authors
Houssam Al-Koussa
Nour El Mais
Hiba Maalouf
Ralph Abi-Habib
Mirvat El-Sibai
Publication date
01-12-2020
Publisher
BioMed Central
Keyword
Metastasis
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01232-9

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