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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 1/2014

01-03-2014 | NON-THEMATIC REVIEW

Oxygen regulates molecular mechanisms of cancer progression and metastasis

Authors: Kartik Gupta, Esha Madan, Muzzammil Sayyid, Hugo Arias-Pulido, Eduardo Moreno, Periannan Kuppusamy, Rajan Gogna

Published in: Cancer and Metastasis Reviews | Issue 1/2014

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Abstract

Oxygen is the basic molecule which supports life and it truly is “god's gift to life.” Despite its immense importance, research on “oxygen biology” has never received the light of the day and has been limited to physiological and biochemical studies. It seems that in modern day biology, oxygen research is summarized in one word “hypoxia.” Scientists have focused on hypoxia-induced transcriptomics and molecular–cellular alterations exclusively in disease models. Interestingly, the potential of oxygen to control the basic principles of biology like homeostatic maintenance, transcription, replication, and protein folding among many others, at the molecular level, has been completely ignored. Here, we present a perspective on the crucial role played by oxygen in regulation of basic biological phenomena. Our conclusion highlights the importance of establishing novel research areas like oxygen biology, as there is great potential in this field for basic science discoveries and clinical benefits to the society.
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Metadata
Title
Oxygen regulates molecular mechanisms of cancer progression and metastasis
Authors
Kartik Gupta
Esha Madan
Muzzammil Sayyid
Hugo Arias-Pulido
Eduardo Moreno
Periannan Kuppusamy
Rajan Gogna
Publication date
01-03-2014
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 1/2014
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-013-9464-2

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