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Magnetic Resonance Materials in Physics, Biology and Medicine
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 6/2019

01-12-2019 | Osteoarthrosis | Research Article

Validation of a novel blinding method for measuring postoperative knee articular cartilage using magnetic resonance imaging

Authors: Rebecca Moyer, Trevor Birmingham, Felix Eckstein, Wolfgang Wirth, Susanne Maschek, Blaine Chronik, J. Robert Giffin

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 6/2019

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Abstract

Objectives

To test PEEK implant-associated MRI artifacts, a method for blinding MRI readers, the repeatability of cartilage thickness measures before and 6 weeks after high tibial osteotomy (HTO), and the sensitivity to change of cartilage thickness 12 months after HTO.

Materials and methods

Ten patients underwent HTO using a PEEK implant and 3 T-MRI before, 6 weeks and 12 months after surgery. Masks were applied to hide implant visibility on 48 MRI pairs, which were assessed by 7 readers (blinded to time). One blinded reader measured femorotibial cartilage thickness from masked MRIs.

Results

No artifacts were produced. Readers were unable to identify scans by time greater than by chance. Cartilage thickness before and 6 weeks after surgery was not significantly different and indicated excellent repeatability. Medial cartilage thickness increases 12 M postoperatively approached statistical significance (p = 0.06), with no lateral changes observed. Half of the participants had an increase in medial cartilage thickness at 12 M that exceeded the minimal detectable change. Standardized response mean values were moderate-to-large.

Discussion

Postoperative measures of cartilage thickness are repeatable, consistent and sensitive to change when artifact is eliminated, and a validated blinding technique is used. These results provide proof of concept for accurately measuring increases in medial knee articular cartilage after medial opening wedge HTO.
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Metadata
Title
Validation of a novel blinding method for measuring postoperative knee articular cartilage using magnetic resonance imaging
Authors
Rebecca Moyer
Trevor Birmingham
Felix Eckstein
Wolfgang Wirth
Susanne Maschek
Blaine Chronik
J. Robert Giffin
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 6/2019
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-019-00766-y

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