Published in:
01-12-2019 | Magnetic Resonance Imaging | Research article
Phase-contrast magnetic resonance imaging for analyzing hemodynamic parameters and wall shear stress of pulmonary arteries in patients with pulmonary arterial hypertension
Authors:
Hung-Hsuan Wang, Wen-Yih Isaac Tseng, Hsi-Yu Yu, Meng-Chu Chang, Hsu-Hsia Peng
Published in:
Magnetic Resonance Materials in Physics, Biology and Medicine
|
Issue 6/2019
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Abstract
Objective
To investigate flow-related parameters in pulmonary arteries of patients with pulmonary arterial hypertension (PAH).
Materials and methods
Eleven PAH patients and twelve control participants were recruited. PAH and controls had similar age and gender distribution. 2D phase-contrast MRI (PC-MRI) was performed in the main, right, and left pulmonary artery (MPA, RPA, and LPA). The flow velocity, wall shear stress (WSS), and oscillatory shear index (OSI) were measured.
Results
PAH patients displayed prolonged acceleration time (Tacce) and increased ratio of flow change to acceleration volume in pulmonary arteries (both P < 0.001). The temporally averaged WSS values of MPA, RPA, and LPA in PAH patients were significantly lower than those of control participants (P < 0.001). The OSI in the pulmonary arteries was higher in PAH patients than control participants (P < 0.05). The ROC analysis indicated the ratio of maximum flow change to acceleration volume, WSS, and Tacce exhibited sufficient sensitivity and specificity to detect patients with PAH. The WSS demonstrated strong correlations with Tacce and the ratio value in the two groups (R2 = 0.78–0.96).
Conclusions
We used a clinically feasible 2D PC-MRI sequence with a reasonable scanning time to compute aforementioned indices. The quantitative parameters provided sufficient information to differentiate PAH patients from control participants.