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Reviews in Endocrine and Metabolic Disorders

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Open Access 01-06-2021 | Obesity

Mammary gland adipocytes in lactation cycle, obesity and breast cancer

Authors: Georgia Colleluori, Jessica Perugini, Giorgio Barbatelli, Saverio Cinti

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 2/2021

Abstract

The mammary gland (MG) is an exocrine gland present in female mammals responsible for the production and secretion of milk during the process of lactation. It is mainly composed by epithelial cells and adipocytes. Among the features that make the MG unique there are 1) its highly plastic properties displayed during pregnancy, lactation and involution (all steps belonging to the lactation cycle) and 2) its requirement to grow in close association with adipocytes which are absolutely necessary to ensure MG’s proper development at puberty and remodeling during the lactation cycle. Although MG adipocytes play such a critical role for the gland development, most of the studies have focused on its epithelial component only, leaving the role of the neighboring adipocytes largely unexplored. In this review we aim to describe evidences regarding MG’s adipocytes role and properties in physiologic conditions (gland development and lactation cycle), obesity and breast cancer, emphasizing the existing gaps in the literature which deserve further investigation.

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Title: Mammary gland adipocytes in lactation cycle, obesity and breast cancer
Authors: Georgia Colleluori
Jessica Perugini
Giorgio Barbatelli
Saverio Cinti
Publication date: 01-06-2021
Publisher: Springer US
Keywords: Obesity
Obesity
Breast Cancer
Lactation
Breast Cancer
Published in: Reviews in Endocrine and Metabolic Disorders / Issue 2/2021
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-021-09633-5

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Obesity Clinical Trial Summary

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

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