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Reviews in Endocrine and Metabolic Disorders

Published in:

01-06-2021 | Obesity

Polyphenols and their anti-obesity role mediated by the gut microbiota: a comprehensive review

Authors: Lissette Duarte, Naschla Gasaly, Carlos Poblete-Aro, Denisse Uribe, Francisca Echeverria, Martin Gotteland, Diego F Garcia-Diaz

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 2/2021

Abstract

Obesity is a global public health problem that results in chronic pathologies such as diabetes, cardiovascular diseases, and cancer. The treatment approach based on energy restriction and promotion of physical activity is ineffective in the long term. Due to the high prevalence of this pathology, complementary treatments such as brown adipose tissue activation (BAT) and white adipose tissue browning (WAT) have been proposed. Dietary polyphenols are plant secondary metabolites that can stimulate browning and thermogenesis of adipose tissue. They have also been shown to prevent body weight gain, and decrease systemic inflammation produced by high-fat diets. Ingested dietary polyphenols that reach the colon are metabolized by the gut microbiota (GM), regulating its composition and generating a great array of metabolites. GM is involved in the production of short chain fatty acids and secondary bile salts that regulate energetic metabolism. The alteration in the composition of GM observed in metabolic diseases such as obesity and type 2 diabetes can be attenuated by polyphenols. Recent studies support the hypothesis that GM would mediate WAT browning and BAT thermogenesis activation induced by polyphenol administration. Together, these results indicate that GM in the presence of polyphenols plays a fundamental role in the control of obesity possible through BAT activation.

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Title: Polyphenols and their anti-obesity role mediated by the gut microbiota: a comprehensive review
Authors: Lissette Duarte
Naschla Gasaly
Carlos Poblete-Aro
Denisse Uribe
Francisca Echeverria
Martin Gotteland
Diego F Garcia-Diaz
Publication date: 01-06-2021
Publisher: Springer US
Keywords: Obesity
Obesity
Respiratory Microbiota
Published in: Reviews in Endocrine and Metabolic Disorders / Issue 2/2021
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-020-09622-0

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Polyphenols and their anti-obesity role mediated by the gut microbiota: a comprehensive review

Abstract

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