Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Cancer Cell International
Published in: Cancer Cell International 1/2020

01-12-2020 | NSCLC | Primary research

The predictive value of lncRNA MIR31HG expression on clinical outcomes in patients with solid malignant tumors

Authors: Chao Tu, Xiaolei Ren, Jieyu He, Shuangqing Li, Lin Qi, Zhixi Duan, Wanchun Wang, Zhihong Li

Published in: Cancer Cell International | Issue 1/2020

Login to get access

Abstract

Background

Emerging studies have explored the prognostic value of MIR31HG in cancers, but its role remains elusive. Herein, we aimed to summarize the prognostic potential of MIR31HG in this study.

Methods

Several databases were searched for literature retrieval on Dec 5, 2019. Overall and subgroup analyses were conducted to measure the relationship between MIR31HG expression and clinical outcomes. Moreover, GEPIA was applied for validation of prognostic value of MIR31HG in tumor patients in TCGA dataset.

Results

Overall, seventeen studies with 2573 patients were enrolled. Compared to counterparts, those patients with high MIR31HG expression tended to have shorter RFS. Notably, MIR31HG overexpression predicted unfavorable OS in lung cancer. By contrast, gastrointestinal cancer patients with elevated MIR31HG expression predicted better OS and disease-free survival. Additionally, MIR31HG overexpression was significantly associated with worse clinicopathological features including advanced tumor stage and LNM in lung cancer, but favorable clinical characteristics in gastrointestinal cancer. Moreover, the positive association between MIR31HG and OS in lung cancer was further confirmed in TCGA dataset.

Conclusion

Overexpression of MIR31HG suggested remarkable association with poor prognosis in terms of OS, tumor stage, and LNM in lung cancer, but favorable prognosis in gastrointestinal cancer. Therefore, MIR31HG may serve as a promising prognostic biomarker in multiple cancers.
Appendix
Available only for authorised users
Literature
1.
2.
Zheng S, Zhang X, Wang X, Li J. MIR31HG promotes cell proliferation and invasion by activating the Wnt/beta-catenin signaling pathway in non-small cell lung cancer. Oncol Lett. 2019;17(1):221–9.PubMed
3.
Huo X, Han S, Wu G, Latchoumanin O, Zhou G, Hebbard L, et al. Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells. Mol Cancer. 2017;16(1):165.PubMedPubMedCentralCrossRef
4.
Shih JW, Chiang WF, Wu ATH, Wu MH, Wang LY, Yu YL, et al. Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1alpha co-activator driving oral cancer progression. Nat Commun. 2017;8:15874.PubMedPubMedCentralCrossRef
5.
Zhang Y, He W, Zhang S. Seeking for correlative genes and signaling pathways with bone metastasis from breast cancer by integrated analysis. Front Oncol. 2019;9:138.PubMedPubMedCentralCrossRef
6.
Yan S, Tang Z, Chen K, Liu Y, Yu G, Chen Q, et al. Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression. J Exp Clin Cancer Res. 2018;37(1):214.PubMedPubMedCentralCrossRef
7.
Yang H, Liu P, Zhang J, Peng X, Lu Z, Yu S, et al. Long noncoding RNA MIR31HG exhibits oncogenic property in pancreatic ductal adenocarcinoma and is negatively regulated by miR-193b. Oncogene. 2016;35(28):3647–57.PubMedCrossRef
8.
9.
10.
Tu C, Ren X, He J, Zhang C, Chen R, Wang W, et al. The value of LncRNA BCAR4 as a prognostic biomarker on clinical outcomes in human cancers. J Cancer. 2019;10(24):5992–6002.PubMedPubMedCentralCrossRef
11.
Zhang C, Ren X, He J, Wang W, Tu C, Li Z. The prognostic value of long noncoding RNA SNHG16 on clinical outcomes in human cancers: a systematic review and meta-analysis. Cancer Cell Int. 2019;19:261.PubMedPubMedCentralCrossRef
12.
Fu D, Lu C, Qu X, Li P, Chen K, Shan L, et al. LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis. Aging. 2019;11(19):8374–85.PubMedPubMedCentralCrossRef
13.
Shi Y, Lu J, Zhou J, Tan X, He Y, Ding J, et al. Long non-coding RNA Loc554202 regulates proliferation and migration in breast cancer cells. Biochem Biophys Res Commun. 2014;446(2):448–53.PubMedCrossRef
14.
Montes M, Nielsen MM, Maglieri G, Jacobsen A, Hojfeldt J, Agrawal-Singh S, et al. The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence. Nat Commun. 2015;6:6967.PubMedCrossRef
15.
Sun Y, Jia X, Wang M, Deng Y. Long noncoding RNA MIR31HG abrogates the availability of tumor suppressor microRNA-361 for the growth of osteosarcoma. Cancer Manag Res. 2019;11:8055–64.PubMedPubMedCentralCrossRef
16.
Ma X, Qi S, Duan Z, Liao H, Yang B, Wang W, et al. Long non-coding RNA LOC554202 modulates chordoma cell proliferation and invasion by recruiting EZH2 and regulating miR-31 expression. Cell Prolif. 2017;50(6).
17.
Eide PW, Eilertsen IA, Sveen A, Lothe RA. Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell-intrinsic properties. Int J Cancer. 2019;144(11):2843–53.PubMedPubMedCentralCrossRef
18.
Zhang H, Wang Z, Wu J, Ma R, Feng J. Long noncoding RNAs predict the survival of patients with colorectal cancer as revealed by constructing an endogenous RNA network using bioinformation analysis. Cancer Med. 2019;8(3):863–73.PubMedPubMedCentralCrossRef
19.
Ding J, Lu B, Wang J, Wang J, Shi Y, Lian Y, et al. Long non-coding RNA Loc554202 induces apoptosis in colorectal cancer cells via the caspase cleavage cascades. J Exp Clin Cancer Res. 2015;34:100.PubMedPubMedCentralCrossRef
20.
Wang B, Jiang H, Wang L, Chen X, Wu K, Zhang S, et al. Increased MIR31HG lncRNA expression increases gefitinib resistance in non-small cell lung cancer cell lines through the EGFR/PI3K/AKT signaling pathway. Oncol Lett. 2017;13(5):3494–500.PubMedPubMedCentralCrossRef
21.
Liu B, Chen Y, Yang J. LncRNAs are altered in lung squamous cell carcinoma and lung adenocarcinoma. Oncotarget. 2017;8(15):24275–91.PubMedCrossRef
22.
Ning P, Wu Z, Hu A, Li X, He J, Gong X, et al. Integrated genomic analyses of lung squamous cell carcinoma for identification of a possible competitive endogenous RNA network by means of TCGA datasets. Peer J. 2018;6:e4254.PubMedCrossRefPubMedCentral
23.
Qin J, Ning H, Zhou Y, Hu Y, Yang L, Huang R. LncRNA MIR31HG overexpression serves as poor prognostic biomarker and promotes cells proliferation in lung adenocarcinoma. Biomed Pharmacother. 2018;99:363–8.PubMedCrossRef
24.
Sui J, Yang S, Liu T, Wu W, Xu S, Yin L, et al. Molecular characterization of lung adenocarcinoma: a potential four-long noncoding RNA prognostic signature. J Cell Biochem. 2019;120(1):705–14.PubMedCrossRef
25.
Nie FQ, Ma S, Xie M, Liu YW, De W, Liu XH. Decreased long noncoding RNA MIR31HG is correlated with poor prognosis and contributes to cell proliferation in gastric cancer. Tumour Biol. 2016;37(6):7693–701.PubMedCrossRef
26.
He A, Chen Z, Mei H, Liu Y. Decreased expression of LncRNA MIR31HG in human bladder cancer. Cancer Biomark. 2016;17(2):231–6.PubMedCrossRef
27.
Augoff K, McCue B, Plow EF, Sossey-Alaoui K. miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. Mol Cancer. 2012;11:5.PubMedPubMedCentralCrossRef
28.
Chen J, Zhu J. Elevated expression levels of long non-coding RNA, Loc554202, are predictive of poor prognosis in cervical cancer. Tohoku J Exp Med. 2017;243(3):165–72.PubMedCrossRef
29.
Ni S, Zhao X, Ouyang L. Long non-coding RNA expression profile in vulvar squamous cell carcinoma and its clinical significance. Oncol Rep. 2016;36(5):2571–8.PubMedCrossRef
30.
Sun K, Zhao X, Wan J, Yang L, Chu J, Dong S, et al. The diagnostic value of long non-coding RNA MIR31HG and its role in esophageal squamous cell carcinoma. Life Sci. 2018;202:124–30.PubMedCrossRef
31.
Ren ZP, Chu XY, Xue ZQ, Zhang LB, Wen JX, Deng JQ, et al. Down-regulation of lncRNA MIR31HG correlated with aggressive clinicopathological features and unfavorable prognosis in esophageal squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 2017;21(17):3866–70.PubMed
32.
Li Y, Xin S, Wu H, Xing C, Duan L, Sun W, et al. High expression of microRNA31 and its host gene LOC554202 predict favorable outcomes in patients with colorectal cancer treated with oxaliplatin. Oncol Rep. 2018;40(3):1706–24.PubMed
33.
Yang LWH, Xiao HJ. Long non-coding RNA Loc554202 expression as a prognostic factor in patients with colorectal cancer. Eur Rev Med Pharmacol Sci. 2016;20(20):4243–7.PubMed
34.
Lin Y, Zhang CS, Li SJ, Li Z, Sun FB. LncRNA LOC554202 promotes proliferation and migration of gastric cancer cells through regulating p21 and E-cadherin. Eur Rev Med Pharmacol Sci. 2018;22(24):8690–7.PubMed
35.
Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47(W1):W556–60.PubMedPubMedCentralCrossRef
36.
Wang R, Ma Z, Feng L, Yang Y, Tan C, Shi Q, et al. LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression. Mol Cancer. 2018;17(1):162.PubMedPubMedCentralCrossRef
37.
38.
He J, Tu C, Liu Y. Role of lncRNAs in aging and age-related diseases. Aging Med. 2018;1(2):158–75.CrossRef
39.
Zou Y, Xu S, Xiao Y, Qiu Q, Shi M, Wang J, et al. Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation. J Clin Invest. 2018;128(10):4510–24.PubMedPubMedCentralCrossRef
40.
Rajbhandari R, McFarland BC, Patel A, Gerigk M, Gray GK, Fehling SC, et al. Loss of tumor suppressive microRNA-31 enhances TRADD/NF-kappaB signaling in glioblastoma. Oncotarget. 2015;6(19):17805–16.PubMedPubMedCentralCrossRef
41.
Dandan W, Jianliang C, Haiyan H, Hang M, Xuedong L. Long noncoding RNA MIR31HG is activated by SP1 and promotes cell migration and invasion by sponging miR-214 in NSCLC. Gene. 2019;692:223–30.PubMedCrossRef
42.
Feng L, Wang R, Lian M, Ma H, He N, Liu H, et al. Integrated analysis of long noncoding rna and mrna expression profile in advanced laryngeal squamous cell carcinoma. PLoS ONE. 2016;11(12):e0169232.PubMedPubMedCentralCrossRef
43.
Yang S, Wang J, Ge W, Jiang Y. Long non-coding RNA LOC554202 promotes laryngeal squamous cell carcinoma progression through regulating miR-31. J Cell Biochem. 2018;119(8):6953–60.PubMedCrossRef
44.
He J, Jin S, Zhang W, Wu D, Li J, Xu J, et al. Long non-coding RNA LOC554202 promotes acquired gefitinib resistance in non-small cell lung cancer through upregulating miR-31 expression. J Cancer. 2019;10(24):6003–13.PubMedPubMedCentralCrossRef
45.
Bar C, Chatterjee S, Thum T. Long noncoding RNAs in cardiovascular pathology, diagnosis, and therapy. Circulation. 2016;134(19):1484–99.PubMedCrossRef
46.
Jin C, Jia L, Huang Y, Zheng Y, Du N, Liu Y, et al. Inhibition of lncRNA MIR31HG promotes osteogenic differentiation of human adipose-derived stem cells. Stem Cells. 2016;34(11):2707–20.PubMedCrossRef
Metadata
Title
The predictive value of lncRNA MIR31HG expression on clinical outcomes in patients with solid malignant tumors
Authors
Chao Tu
Xiaolei Ren
Jieyu He
Shuangqing Li
Lin Qi
Zhixi Duan
Wanchun Wang
Zhihong Li
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01194-y

Other articles of this Issue 1/2020

Cancer Cell International 1/2020 Go to the issue

Primary research

LINC01094 triggers radio-resistance in clear cell renal cell carcinoma via miR-577/CHEK2/FOXM1 axis

Primary research

Differential genetic mutations of ectoderm, mesoderm, and endoderm-derived tumors in TCGA database

Review

Circular RNAs and esophageal cancer

Primary research

Cyclin H predicts the poor prognosis and promotes the proliferation of ovarian cancer

Review

The relationship between TRAF6 and tumors

Primary research

LOXL1-AS1 contributes to the proliferation and migration of laryngocarcinoma cells through miR-589-5p/TRAF6 axis
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits