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Cancer Cell International
Published in: Cancer Cell International 1/2020

01-12-2020 | Metastasis | Review

Circular RNAs and esophageal cancer

Authors: Xiaoqing Zhang, Ning Lu, Li Wang, Yixuan Wang, Minna Li, Ying Zhou, Honglin Yan, Manli Cui, Mingxin Zhang, Lingmin Zhang

Published in: Cancer Cell International | Issue 1/2020

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Abstract

As a new kind of RNA, circular RNA (circRNA) is a endogenous non-coding RNA with circular structure, which has the characteristics of universality, stability, conservatism and specificity. CircRNA can specifically bind to microRNAs (miRNAs) in the form of competitive endogenous RNA, thus directly or indirectly regulating the expression of related genes. In addition to the role of sponge, circRNA also regulates parental gene expression, transcriptional translation and protein modification; and it can be used as a biomarker to develop potential diagnosis and treatment methods and evaluate prognosis. Due to changes in dietary habits and genetic factors, the morbidity and mortality of esophageal cancer (EC) in the world are still high, and are prone to early metastasis. Although the diagnosis and treatment techniques have been improved in recent years, the early diagnosis of EC is not common, and the 5-year survival rate of patients is still very low. This article reviews the function and significance of circRNA and discusses the research progress of circRNA as biomarkers in EC.
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Metadata
Title
Circular RNAs and esophageal cancer
Authors
Xiaoqing Zhang
Ning Lu
Li Wang
Yixuan Wang
Minna Li
Ying Zhou
Honglin Yan
Manli Cui
Mingxin Zhang
Lingmin Zhang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01451-0

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