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01-11-2015 | Original Article

Novel method for genotyping clinical herpes simplex virus type 1 isolates

Authors: Brigitte Glück, Susanne Möbius, Florian Pfaff, Roland Zell, Andreas Sauerbrei

Published in: Archives of Virology | Issue 11/2015

Abstract

Up to now, three distinct genotypes, A, B and C, of herpes simplex virus type 1 (HSV-1), based on polymorphisms in the US4 and US7 genes, have been reported. Here, we propose to include an additional polymorphism of the US2 gene. The refined genotyping method was validated using 423 clinical isolates from patients with different HSV-1 diseases. The proportions of three US2 genotypes were A, 46.6 %; B, 23.2 %; and C, 30.2 %. Genotype A of US2 and US4/US7 showed a highly significant correlation. In addition, the frequency of genotype A was significantly higher in women than in men with herpes labialis.

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Title: Novel method for genotyping clinical herpes simplex virus type 1 isolates
Authors: Brigitte Glück
Susanne Möbius
Florian Pfaff
Roland Zell
Andreas Sauerbrei
Publication date: 01-11-2015
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 11/2015
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-015-2568-y

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