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Archives of Virology
Published in: Archives of Virology 11/2015

01-11-2015 | Original Article

Antiviral effect of lithium chloride on infection of cells by canine parvovirus

Authors: Pei Zhou, Xinliang Fu, Zhongshan Yan, Bo Fang, San Huang, Cheng Fu, Malin Hong, Shoujun Li

Published in: Archives of Virology | Issue 11/2015

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Abstract

Canine parvovirus type 2 causes significant viral disease in dogs, with high morbidity, high infectivity, and high mortality. Lithium chloride is a potential antiviral drug for viruses. We determined the antiviral effect of Lithium Chloride on canine parvovirus type 2 in feline kidney cells. The viral DNA and proteins of canine parvovirus were suppressed in a dose-dependent manner by lithium chloride. Further investigation verified that viral entry into cells was inhibited in a dose-dependent manner by lithium chloride. These results indicated that lithium chloride could be a potential antiviral drug for curing dogs with canine parvovirus infection. The specific steps of canine parvovirus entry into cells that are affected by lithium chloride and its antiviral effect in vivo should be explored in future studies.
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Metadata
Title
Antiviral effect of lithium chloride on infection of cells by canine parvovirus
Authors
Pei Zhou
Xinliang Fu
Zhongshan Yan
Bo Fang
San Huang
Cheng Fu
Malin Hong
Shoujun Li
Publication date
01-11-2015
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 11/2015
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-015-2577-x

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