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Breast Cancer Research and Treatment
Published in: Breast Cancer Research and Treatment 1/2011

01-01-2011 | Brief Report

No evidence for an association of human papillomavirus and breast carcinoma

Authors: Raimundo Gerônimo Silva Jr., Benedito Borges da Silva

Published in: Breast Cancer Research and Treatment | Issue 1/2011

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Abstract

Breast cancer represents a serious public health problem worldwide, for its high incidence, morbidity, mortality, and its high cost treatment. It is known that breast cancer is a multifactorial disease, possessing various risk factors, among which include hormonal factors, genetic and environmental. The role of viruses in breast carcinogenesis is controversial. This study aims to evaluate the expression of HPV 6, 11, 16, and 18 by polymerase chain reaction (PCR) in invasive ductal breast carcinoma. We analyzed 90 women diagnosed with invasive ductal breast carcinoma, of which the extracted DNA was amplified, quantified and tested for DNA subtypes 6, 11, 16, and 18 by PCR. The research carried out in 79 samples of HPV DNA, proved negative. Our study demonstrates no association between the most prevalent types of HPV and breast cancer.
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Metadata
Title
No evidence for an association of human papillomavirus and breast carcinoma
Authors
Raimundo Gerônimo Silva Jr.
Benedito Borges da Silva
Publication date
01-01-2011
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 1/2011
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-010-1129-z

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