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Breast Cancer Research and Treatment
Published in: Breast Cancer Research and Treatment 1/2008

01-05-2008 | Clinical Trial

No evidence of Human papillomavirus DNA sequences in invasive breast carcinoma

Authors: Patricia de Cremoux, Martine Thioux, Ingrid Lebigot, Brigitte Sigal-Zafrani, Rémy Salmon, Xavier Sastre-Garau, For the Institut Curie Breast Group

Published in: Breast Cancer Research and Treatment | Issue 1/2008

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Abstract

Breast cancer is one of the most frequently diagnosed cancers in women in France, but its aetiology remains unknown. Viruses including Epstein-Barr virus (EBV), a human equivalent of murine mammary tumour virus (MMTV) and human papillomavirus (HPV) have been detected in benign breast tissues and breast tumours and are considered to be involved in the aetiology of breast cancer. The aim of this study was to determine the prevalence of high-risk oncogenic HPVs in breast carcinoma from French patients. Fifty unselected DNA samples extracted from invasive breast carcinoma tissues were analysed. Polymerase chain reaction (PCR) was performed to amplify both consensus GP5 + /GP6 + HPV sequences and specific sequences for HPV types 16, 18, 33, 45 and 6-11. No HPV-DNA sequences were detected in our series of 50 samples. These data argue against the role of oncogenic HPV in the pathogenesis of breast cancer.
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Metadata
Title
No evidence of Human papillomavirus DNA sequences in invasive breast carcinoma
Authors
Patricia de Cremoux
Martine Thioux
Ingrid Lebigot
Brigitte Sigal-Zafrani
Rémy Salmon
Xavier Sastre-Garau
For the Institut Curie Breast Group
Publication date
01-05-2008
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 1/2008
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-007-9626-4

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