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Inflammation

26-04-2024 | Mycobacterium Tuberculosis | REVIEW

Bacillus Calmette-Guérin (BCG)-Induced Protection in Brain Disorders

Authors: Khiany Mathias, Richard Simon Machado, Solange Stork, Carla Damasio Martins, Amanda Christine da Silva Kursancew, Victória Linden de Rezende, Cinara Ludvig Gonçalves, Tatiana Barichello, Josiane Somariva Prophiro, Fabricia Petronilho

Published in: Inflammation

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Abstract

The Bacille Calmette-Guerin (BCG) vaccine is one of the most widely used vaccines in the world for the prevention of tuberculosis. Its immunological capacity also includes epigenetic reprogramming, activation of T cells and inflammatory responses. Although the main usage of the vaccine is the prevention of tuberculosis, different works have shown that the effect of BCG can go beyond the peripheral immune response and be linked to the central nervous system by modulating the immune system at the level of the brain. This review therefore aims to describe the BCG vaccine, its origin, its relationship with the immune system, and its involvement at the brain level.
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Metadata
Title
Bacillus Calmette-Guérin (BCG)-Induced Protection in Brain Disorders
Authors
Khiany Mathias
Richard Simon Machado
Solange Stork
Carla Damasio Martins
Amanda Christine da Silva Kursancew
Victória Linden de Rezende
Cinara Ludvig Gonçalves
Tatiana Barichello
Josiane Somariva Prophiro
Fabricia Petronilho
Publication date
26-04-2024
Publisher
Springer US
Published in
Inflammation
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-024-02018-1
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