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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

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Open Access 01-12-2021 | Multiple Sclerosis | Review

MicroRNAs in central nervous system disorders: current advances in pathogenesis and treatment

Authors: Mona Hussein, Rehab Magdy

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2021

Abstract

MicroRNAs (miRNAs) are a class of short, non-coding, regulatory RNA molecules that function as post transcriptional regulators of gene expression. Altered expression of multiple miRNAs was found to be extensively involved in the pathogenesis of different neurological disorders including Alzheimer’s disease, Parkinson’s disease, stroke, epilepsy, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease. miRNAs are implicated in the pathogenesis of excitotoxicity, apoptosis, oxidative stress, inflammation, neurogenesis, angiogenesis, and blood–brain barrier protection. Consequently, miRNAs can serve as biomarkers for different neurological disorders. In recent years, advances in the miRNA field led to identification of potentially novel prospects in the development of new therapies for incurable CNS disorders. MiRNA-based therapeutics include miRNA mimics and inhibitors that can decrease or increase the expression of target genes. Better understanding of the mechanisms by which miRNAs are implicated in the pathogenesis of neurological disorders may provide novel targets to researchers for innovative therapeutic strategies.

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Title: MicroRNAs in central nervous system disorders: current advances in pathogenesis and treatment
Authors: Mona Hussein
Rehab Magdy
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keywords: Multiple Sclerosis
Huntington's Disease
Amyotrophic Lateral Sclerosis
Stroke
Parkinson's Disease
Alzheimer's Disease
Alzheimer's Disease
Central Nervous System Trauma
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery / Issue 1/2021
Electronic ISSN: 1687-8329
DOI: https://doi.org/10.1186/s41983-021-00289-1

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Springer Medicine

MicroRNAs in central nervous system disorders: current advances in pathogenesis and treatment

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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