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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

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Open Access 01-12-2021 | COVID-19 | Review

Neurologic manifestations of COVID-19 infection in Asia: a systematic review

Authors: I. Putu Eka Widyadharma, Alvin Hendellyn, A. A. A. Putri Laksmi Dewi, I. Made Oka Adnyana, D. P. G. Purwa Samatra, Desak Ketut Indrasari Utami

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2021

Abstract

Background

COVID-19 infection can show various manifestation, including neurologic manifestations, such as anosmia, ageusia, or dysgeusia, and causes the neurologic disorder such as stroke, Guillain-Barre syndrome, encephalopathy, and many more.

Aim

To briefly review neurologic manifestation in COVID-19 infection in the Asia region (South East Asia and the Western Pacific Region).

Material and methods

This review uses the PRISMA statement and checklist. The source for reviewed article was performed in PubMed that were published between December 2019 to September 2020 with the latest 1 year of publication. Study titles were first screened, then reviewed by title and abstract and then the last review, we tested full text and applied eligibility criteria.

Results

We found a total of 9 retrieved articles from the electronic database. Among these 9 articles, 5 of them are case report, 1 case series, 1 prospective multi-center cohort study, 1 retrospective multi-center study, and 1 retrospective observational study. All articles reported confirmed COVID-19, confirmation by positive swab test using the real-time RT-PCR method, with neurologic manifestations, disorder, or syndrome on presentation or found during hospital stay. In case of neurologic disorder or syndrome, the studies reported encephalitis and ADEM, acute cerebrovascular disease, acute symptomatic seizure, and Guillain-Barré syndrome with acute cerebrovascular disease as the most common neurologic disorder associated with COVID-19 infection, followed by encephalitis.

Conclusion

COVID-19 also affects the brain, which may result in a global or focal neurologic manifestation. Healthcare provider treating patient with COVID-19 infection should also be aware of neurologic manifestation associated with COVID-19 infection to improve patient’s outcome.

Guillain-Barre syndrome, encephalopathy, and many more. This review will briefly review neurologic manifestation in COVID-19 infection in the Asian region (South East Asia and the Western Pacific Region. A total of 9 retrieved articles from the electronic database reported confirmed COVID-19, confirmation by RT-PCR method, with neurologic manifestation, disorder, or syndrome on presentation or found during hospital stay. Healthcare provider treating patient with COVID-19 infection should also be aware of neurologic manifestation associated with COVID-19 infection to improve patient’s outcome.

Kesehatan K. Pedoman Pencegahan dan Pengendalian Corona Virus deases (Covid-19). Kementrian Kesehat. 2020;5:178 Available from: https://covid19.go.id/storage/app/media/Protokol/REV-05_Pedoman_P2_COVID-19_13_Juli_2020.pdf.

(OMS) WHO. COVID-19 Weekly Epidemiological Update. 2020;(November):1;4. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20201012-weekly-epi-update-9.pdf

Gülpınar Ö, Güçlü AG. How to write a review article? Derleme makalesi nasıl yazılır? 2013; Available from: www.turkishjournalofurology.com. [cited 2021 Jan 2].

Koh JS, De Silva DA, Quek AML, Chiew HJ, Tu TM, Seet CYH, et al. Neurology of COVID-19 in Singapore. J Neurol Sci. 2020;418:117118 Available from: http://www.jns-journal.com/article/S0022510X2030455X/fulltext. cited 2021 Jan 2].

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683–90. Available from: https://jamanetwork.com/. [cited 2021 Jan 2].

Lu L, Xiong W, Liu D, Liu J, Yang D, Li N, et al. New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: a retrospective multicenter study. Epilepsia. 2020;61(6):e49–53. Available from: https://pubmed.ncbi.nlm.nih.gov/32304092/. [cited 2021 Jan 2].

Chandrasekaran B, Fernandes S. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus. The COVID-19 resource centre is hosted on Elsevier Connect , the company’ s public news and information website. Diabetes Metab Syndr. 2020;14(4)(January):337–9.

Kamal YM, Abdelmajid Y, Al Madani AAR. Cerebrospinal fluid confirmed COVID-19-associated encephalitis treated successfully. BMJ Case Rep. 2020;13(9):1–5.

Khalifa M, Zakaria F, Ragab Y, Saad A, Bamaga A, Emad Y, et al. Guillain-Barré syndrome associated with severe acute respiratory syndrome coronavirus 2 detection and coronavirus disease 2019 in a child. J Pediatric Infect Dis Soc. 2020;9(4):510–3 Available from: https://pubmed.ncbi.nlm.nih.gov/32652520/. [cited 2021 Jan 2].CrossRef

10.

Wang M, Li T, Qiao F, Wang L, Li C, Gong Y. Coronavirus disease 2019 associated with aggressive neurological and mental abnormalities confirmed based on cerebrospinal fluid antibodies: a case report. Medicine (Baltimore). 2020;99(36):e21428. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478433/. [cited 2021 Jan 2].

11.

Kwon DH, Do Y, Eun MY, Lee J, Park H, Sohn S Il, et al. Characteristics of acute stroke in patients with coronavirus disease 2019 and challenges in stroke management during an epidemic. J Korean Med Sci [Internet]. 2020;35(35). Available from: https://pubmed.ncbi.nlm.nih.gov/32893524/. [cited 2021 Jan 2].

12.

Wada S, Nagasaki Y, Arimizu Y, Shimo M, Matsukuma Y, Okamoto M, et al. Neurological disorders identified during treatment of a SARS-CoV-2 infection. Intern Med. 2020;59(17):2187–9. Available from: https://pubmed.ncbi.nlm.nih.gov/32713924/. [cited 2021 Jan 2].

13.

Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, et al. Neurological associations of COVID-19. 19, p. 767–783 2020 Lancet Neurol. Lancet Publishing Group; [cited 2021 Jan 2]. Available from: https://doi.org/10.1016/S1474-4422(20)30221-0

14.

Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395:1033–4 Lancet Publishing Group; . Available from: https://pubmed.ncbi.nlm.nih.gov/32192578/. [cited 2021 Jan 2].

15.

Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers DAMPJ, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res [Internet]. 2020;191:145–7. Available from: https://pubmed.ncbi.nlm.nih.gov/32291094/. [cited 2021 Jan 2].

16.

Aghagoli G, Gallo Marin B, Katchur NJ, Chaves-Sell F, Asaad WF, Murphy SA. Neurological Involvement in COVID-19 and Potential Mechanisms: A Review [Internet]. Neurocritical Care. Springer; 2020 [cited 2021 Jan 2]. p. 1. Available from: https://pubmed.ncbi.nlm.nih.gov/32661794/.

17.

Mice Transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus inf ection | Request PDF. Available from: https://www.researchgate.net/publication/5872492_Mice_Transgenic_for_human_angiotensin-converting_enzyme_2_provide_a_model_for_SARS_coronavirus_inf_ection. [cited 2021 Jan 2].

18.

Huang KJ, Su IJ, Theron M, Wu YC, Lai SK, Liu CC, et al. An interferon-γ-related cytokine storm in SARS patients. J Med Virol. 2005;75(2):185–94 Available from: https://pubmed.ncbi.nlm.nih.gov/15602737/. [cited 2021 Jan 2].

19.

Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci. 2001;2(10):734–44.

20.

Sejvar JJ, Baughman AL, Wise M, Morgan OW. Population incidence of Guillain-Barré syndrome: A systematic review and meta-analysis. Neuroepidemiology. 2011;36:123–33 Neuroepidemiology; Available from: https://pubmed.ncbi.nlm.nih.gov/21422765/. [cited 2021 Jan 2].

21.

Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol. 2020 19, p. 383–384. Lancet Publishing Group; Available from: https://doi.org/10.1016/S1474-4422(20)30109-5. [cited 2021 Jan 2].

Title: Neurologic manifestations of COVID-19 infection in Asia: a systematic review
Authors: I. Putu Eka Widyadharma
Alvin Hendellyn
A. A. A. Putri Laksmi Dewi
I. Made Oka Adnyana
D. P. G. Purwa Samatra
Desak Ketut Indrasari Utami
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keywords: COVID-19
Guillain-Barré Syndrome
Cerebrovascular Disease
Encephalitis
Stroke
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery / Issue 1/2021
Electronic ISSN: 1687-8329
DOI: https://doi.org/10.1186/s41983-021-00279-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Neurologic manifestations of COVID-19 infection in Asia: a systematic review

Abstract

Background

Aim

Material and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Aim

Material and methods

Results

Conclusion

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